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Influence of Diabetes Mellitus on Long-Term (Five-Year) Outcomes of Drug-Eluting Stents and Coronary Artery Bypass Grafting for Multivessel Coronary Revascularization
- Source :
- The American Journal of Cardiology. 109:1548-1557
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Diabetes mellitus is a major risk factor for coronary artery disease (CAD) and for diffuse and progressive atherosclerosis. We evaluated the outcomes of drug-eluting stent (DES) placement and coronary artery bypass grafting (CABG) in 891 diabetic patients (489 for DES implantation and 402 for CABG) and 2,151 nondiabetic patients (1,058 for DES implantation and 1,093 for CABG) with multivessel CAD treated from January 2003 through December 2005 and followed up for a median 5.6 years. Outcomes of interest included death; the composite outcome of death, myocardial infarction (MI), or stroke; and repeat revascularization. In diabetic patients, after adjusting for baseline covariates, 5-year risk of death (hazard ratio 1.01, 95% confidence interval 0.77 to 1.33, p = 0.96) and the composite of death, MI, or stroke (hazard ratio 1.03, 95% confidence interval 0.80 to 1.31, p = 0.91) were similar in patients undergoing DES or CABG. However, rate of repeat revascularization was significantly higher in the DES group (hazard ratio 3.69, 95% confidence interval 2.64 to 5.17, p
- Subjects :
- Male
medicine.medical_specialty
Paclitaxel
medicine.medical_treatment
Myocardial Infarction
Coronary Artery Disease
Coronary artery disease
Diabetes mellitus
Internal medicine
Diabetes Mellitus
medicine
Humans
Prospective Studies
Registries
cardiovascular diseases
Myocardial infarction
Angioplasty, Balloon, Coronary
Coronary Artery Bypass
Risk factor
Stroke
Proportional Hazards Models
Sirolimus
business.industry
Hazard ratio
Stent
Drug-Eluting Stents
Middle Aged
medicine.disease
Confidence interval
Retreatment
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 00029149
- Volume :
- 109
- Database :
- OpenAIRE
- Journal :
- The American Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....c4168ab81069ab06854fcf57d06c42fd