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The Role of Serpin and Cystatin Antiproteases in Mucosal Innate Immunity and their Defense against HIV
- Source :
- American Journal of Reproductive Immunology. 71:12-23
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Antiproteases play diverse roles in nature, from regulating protease activity to innate defense against microorganisms. Recently, antiproteases have been shown to play important roles in HIV pathogenesis including, inhibiting HIV binding and replication and reducing activation and inflammation of susceptible cells. They have also been implicated as one of the initial host responders, in plasma, to control replication of HIV. More recently, antiproteases expressed at the mucosal surface have been linked to reduced susceptibility to HIV infection in HIV-exposed sero-negative individuals. These factors are expressed in the epithelial layer of the female genital tract, thus at the frontline of defense against mucosal infection. This review focuses on the specific antimicrobial roles of antiproteases, focusing on serpins and cystatins, with an emphasis on their known and potential roles in HIV infection. Their potential as therapeutic interventions to combat HIV is also discussed.
- Subjects :
- medicine.medical_treatment
Immunology
HIV Infections
Inflammation
Biology
Serpin
Virus Replication
Antiviral Agents
Pathogenesis
medicine
Animals
Humans
Immunology and Allergy
Protease Inhibitors
Serpins
Mucous Membrane
Protease
Innate immune system
HIV
virus diseases
Obstetrics and Gynecology
Epithelial Cells
Genitalia, Female
Antimicrobial
Cystatins
Immunity, Innate
Mucosal Infection
Reproductive Medicine
Female
Cystatin
medicine.symptom
Subjects
Details
- ISSN :
- 10467408
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- American Journal of Reproductive Immunology
- Accession number :
- edsair.doi.dedup.....c414c5b705b8cda4356be45e3ee3fed0