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Progress of malignant mesothelioma research in basic science: A review of the 14th international conference of the international mesothelioma interest group (iMig2018)
- Source :
- Lung cancer, Vol. 127 (2019) pp. 138-145
- Publication Year :
- 2018
-
Abstract
- Here we summarize the most recent update of mesothelioma research in basic science presented at the 14th iMig2018 international conference. The symposium of basic science track mainly focused on the drivers of mesothelioma initiation and progression, molecular pathogenesis, and perspectives on potential therapeutic approaches. This review covers several promising fields including strategies efficiently inhibiting YAP/TAZ functions or their critical downstream targets, heparanase inhibitors, RAN depletion, and MIF/CD74 inhibitors that may be developed as novel therapeutic approaches. In addition, targeting mesothelioma stem cells by depleting M2-polarized macrophages in tumor microenvironment or blocking Tnfsf18 (GITRL)-GITR signalling might be translated into therapeutic modalities in mesothelioma treatment.
- Subjects :
- 0301 basic medicine
Pulmonary and Respiratory Medicine
Mesothelioma
Cancer Research
Lung Neoplasms
Basic science
10255 Clinic for Thoracic Surgery
International Cooperation
Pleural Neoplasms
International mesothelioma interest group (iMig)
610 Medicine & health
Antineoplastic Agents
Therapeutic approach
03 medical and health sciences
0302 clinical medicine
Tumor Microenvironment
Medicine
Animals
Humans
1306 Cancer Research
Malignant pleural mesothelioma (MPM)
Molecular pathogenesis
Molecular Targeted Therapy
Tumor microenvironment
ddc:617
business.industry
Research
Mesothelioma, Malignant
Congresses as Topic
medicine.disease
Therapeutic modalities
030104 developmental biology
Oncology
2740 Pulmonary and Respiratory Medicine
030220 oncology & carcinogenesis
Public Opinion
Interest group
Cancer research
2730 Oncology
business
Asbestos exposure
Subjects
Details
- ISSN :
- 18728332 and 01695002
- Volume :
- 127
- Database :
- OpenAIRE
- Journal :
- Lung cancer (Amsterdam, Netherlands)
- Accession number :
- edsair.doi.dedup.....c402806ed1891e01db7ec4e6d08f7f43