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Renal arterial blood flow measurement by breath-held MRI: Accuracy in phantom scans and reproducibility in healthy subjects
- Source :
- Magnetic Resonance in Medicine. 63:940-950
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- This study evaluates reliability of current technology for measurement of renal arterial blood flow by breath-held velocity-encoded MRI. Overall accuracy was determined by comparing MRI measurements with known flow in controlled-flow-loop phantom studies. Measurements using prospective and retrospective gating methods were compared in phantom studies with pulsatile flow, not revealing significant differences. Phantom study results showed good accuracy, with deviations from true flow consistently below 13% for vessel diameters 3mm and above. Reproducibility in human subjects was evaluated by repeated studies in six healthy control subjects, comparing immediate repetition of the scan, repetition of the scan plane scouting, and week-to-week variation in repeated studies. The standard deviation in the 4-week protocol of repeated in vivo measurements of single-kidney renal flow in normal subjects was 59.7 mL/min, corresponding with an average coefficient of variation of 10.55%. Comparison of renal arterial blood flow reproducibility with and without gadolinium contrast showed no significant differences in mean or standard deviation. A breakdown among error components showed corresponding marginal standard deviations (coefficients of variation) 23.8 mL/min (4.21%) for immediate repetition of the breath-held flow scan, 39.13 mL/min (6.90%) for repeated plane scouting, and 40.76 mL/min (7.20%) for weekly fluctuations in renal blood flow.
- Subjects :
- Adult
Gadolinium DTPA
Male
medicine.medical_specialty
Coefficient of variation
Cardiac-Gated Imaging Techniques
Pulsatile flow
Contrast Media
Kidney
Article
Standard deviation
Imaging phantom
Renal Artery
medicine.artery
Image Processing, Computer-Assisted
Humans
Medicine
Radiology, Nuclear Medicine and imaging
Renal artery
Reproducibility
medicine.diagnostic_test
Phantoms, Imaging
business.industry
Reproducibility of Results
Magnetic resonance imaging
Magnetic Resonance Imaging
Pulsatile Flow
Renal blood flow
Female
Radiology
business
Nuclear medicine
Blood Flow Velocity
Subjects
Details
- ISSN :
- 15222594 and 07403194
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Magnetic Resonance in Medicine
- Accession number :
- edsair.doi.dedup.....c3f63f3940dfaf01c1cddc7598121626