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A nationwide survey of lymphangioleiomyomatosis in Korea: recent increase in newly diagnosed patients
- Source :
- Journal of Korean Medical Science
- Publication Year :
- 2009
-
Abstract
- In 2007, the Korean Interstitial Lung Disease Society had collected clinical data of patients who have diagnosed as Lymphangioleiomyomatosis (LAM) since 1990 through nationwide survey, which showed that LAM patients had increased sharply after 2004. The present study was performed to show the clinical features of Korean patients with LAM, and to establish the reason for the recent increase in the diagnosis. All 63 patients were women and the mean age at diagnosis was 36 yr. The most common presenting symptom was dyspnea and 8 patients had tuberous sclerosis complex. The survival rate at 5 yr after diagnosis was 84%. Compared with patients diagnosed after 2004 (n= 34 ), the patients diagnosed before 2004 (n= 29 ) complained with dyspnea more (P = 0.016) and had lower FEV 1 % predicted (P= 0 . 003 ), and DLco% predicted (P= 0 . 042 ). The higher proportion of patients diagnosed after 2004 showed the normal chest radiography, and they were detected by routine chest CT screening (P= 0 . 016 ). This study showed that clinical features of Korean patients with LAM were not different from those reported elsewhere. It is concluded that the reason for the increase of newly diagnosed patients is the result of increase in detection of the early stage LAM by the widespread use of chest CT screening.
- Subjects :
- Adult
medicine.medical_specialty
Lung Neoplasms
Radiography
Respiratory Diseases
Newly diagnosed
Tuberous sclerosis
DLCO
Internal medicine
Republic of Korea
medicine
Humans
Lymphangioleiomyomatosis
Registries
Stage (cooking)
Survival rate
Aged
Korea
business.industry
Interstitial lung disease
General Medicine
Middle Aged
medicine.disease
Surgery
Respiratory Function Tests
Survival Rate
Early Diagnosis
Female
Original Article
business
Tomography, X-Ray Computed
Subjects
Details
- ISSN :
- 15986357
- Volume :
- 25
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of Korean medical science
- Accession number :
- edsair.doi.dedup.....c3f4b33a56eb0b17cde44fa78f38a17c