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Evolution patterns of SARS-CoV-2: Snapshot on its genome variants
- Source :
- Biochemical and Biophysical Research Communications
- Publication Year :
- 2021
-
Abstract
- An acute respiratory syndrome (COVID-19), caused by a novel coronavirus (SARS-CoV-2) with a high rate of morbidity and elevate mortality, has emerged as one of the most important threats to humankind in the last centuries. Rigorous determination of SARS-CoV-2 infectivity is very difficult owing to the continuous evolution of the virus, with its single nucleotide polymorphism (SNP) variants and many lineages. However, it is urgently necessary to study the virus in depth, to understand the mechanism of its pathogenicity and virulence, and to develop effective therapeutic strategies. The present contribution summarizes in a succinct way the current knowledge on the evolutionary and structural features of the virus, with the aim of clarifying its mutational pattern and its possible role in the ongoing pandemic.
- Subjects :
- 0301 basic medicine
Evolution
viruses
Biophysics
Virulence
Single-nucleotide polymorphism
Genome, Viral
Computational biology
Biology
medicine.disease_cause
Biochemistry
Genome
Article
Virus
Evolution, Molecular
03 medical and health sciences
0302 clinical medicine
Pandemic
medicine
SNP
Humans
Viral
Molecular Biology
Phylogeny
Coronavirus
Mechanism (biology)
SARS-CoV-2
COVID-19
Molecular
Cell Biology
Evolution pattern
Mutation
030104 developmental biology
030220 oncology & carcinogenesis
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....c3f305f1eb651024700285d5d24488f9