QCM sensors coated with calix[4]arenes bearing sensitive chiral moieties for chiral discrimination of 1-phenylethylamine enantiomers

WOS: 000485967900003
This article describes the enantiomeric discrimination properties of new chiral calix[4]arene derivatives bearing (S)-/(R)-1-phenylethylamine moieties (5a and 5b, respectively) towards the 1-phenylethylamine enantiomers on QCM surface. Initial experiments demonstrated that the 5b coated QCM sensor was the most effective sensing material for enantiomeric discrimination of (R)-/(S)-1-phenylethylamine by exhibiting much more sensing ability towards (R)-enantiomer than (S)-enantiomer. Sensitivity, detection limit and time constant of the 5b coated QCM sensor has been were calculated as 0.082 Hz/mu M, 2.7 mu M, and 319.2 s, respectively. Additionally, effects of calixarene content and different coating technique on enantiomeric discrimination, and Langmuir and Freundlich isotherms of the sensing results also were studied. As a result, it has been demonstrated that the coating of QCM sensor with a chiral calix[4]arene (5b) having (S)-1-phenylethylamine moieties provides substantially enantiomeric discrimination of 1-phenylethylamine enantiomers.
Technical Research Council of Turkey (TUBITAK-Grant) [115Z249]; Research Foundation of the Selcuk UniversitySelcuk University [16401003]; Konya, Turkey
We thank the Technical Research Council of Turkey (TUBITAK-Grant No. 115Z249) and the Research Foundation of the Selcuk University (SUBAP-Grant No. 16401003), Konya, Turkey and for financial support of this work produced from Egemen Ozcelik's M.Sc. Thesis.