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Macroporous Biodegradable Cryogels of Synthetic Poly(α-amino acids)
- Source :
- Biomacromolecules. 16(11)
- Publication Year :
- 2015
-
Abstract
- We present an investigation of the preparation of highly porous hydrogels based on biodegradable synthetic poly(α-amino acid) as potential tissue engineering scaffolds. Covalently cross-linked gels with permanent pores were formed under cryogenic conditions by free-radical copolymerization of poly[N(5)-(2-hydroxyethyl)-L-glutamine-stat-N(5)-(2-methacryloyl-oxy-ethyl)-L-glutamine] (PHEG-MA) with 2-hydrohyethyl methacrylate (HEMA) and, optionally, N-propargyl acrylamide (PrAAm) as minor comonomers. The morphology of the cryogels showed interconnected polyhedral or laminar pores. The volume content of communicating water-filled pores was >90%. The storage moduli of the swollen cryogels were in the range of 1-6 kPa, even when the water content was >95%. The enzymatic degradation of a cryogel corresponded to the decrease in its storage modulus during incubation with papain, a model enzyme with specificity analogous to wound-healing enzymes. It was shown that cryogels with incorporated alkyne groups can easily be modified with short synthetic peptides using azide-alkyne cycloaddition "click" chemistry, thus providing porous hydrogel scaffolds with biomimetic features.
- Subjects :
- Polymers and Plastics
Polymers
Bioengineering
Biocompatible Materials
Methacrylate
Polymerization
Biomaterials
chemistry.chemical_compound
Biomimetics
Polymer chemistry
Materials Chemistry
Copolymer
Amino Acids
chemistry.chemical_classification
Acrylamides
Tissue Engineering
Tissue Scaffolds
Chemistry
technology, industry, and agriculture
Dynamic mechanical analysis
Polymer
Morphinans
Acrylamide
Self-healing hydrogels
Click chemistry
Methacrylates
Click Chemistry
Peptides
Porosity
Cryogels
Subjects
Details
- ISSN :
- 15264602
- Volume :
- 16
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Biomacromolecules
- Accession number :
- edsair.doi.dedup.....c3d64d782c87e973c1830d2ed46c7fb4