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The tau A0 allele in Parkinson's disease
- Source :
- Movement disorders : official journal of the Movement Disorder Society. 16(3)
- Publication Year :
- 2001
-
Abstract
- Parkinson's disease (PD) is primarily an α-synucle- inopathy, rather than a tauopathy, but there is evidence for an indirect association of tau with the pathogenetic process in PD. We therefore assessed the frequency in PD of the tau A0 allele, a dinucleotide repeat marker that has been associated with a sporadic tauopathy, progressive supranuclear palsy (PSP). We found the A0 allele to comprise 79.2% of 758 alleles from PD patients and 71.2% of 264 control alleles (P = 0.008). We also performed a meta-analysis of three previous reports, two of which failed to produce statistically significant results. Taken together, they also support a PD/A0 allelic association, even after correction for misdiagnosis of PSP as PD (P< 0.001). The A0/A0 genotype frequency in our patients (62.3%) did not differ significantly from that in controls (53.0%, P = 0.062), but the meta-analysis, even after correction for misdiagnosis, showed a significant result, with P = 0.002. The frequency of A0 allele and the A0/A0 genotype were compatible with Hardy-Weinberg equilibrium. The frequency of the A0 allele and the A0/A0 genotype in our patients with familial PD was not significantly greater than in those with sporadic PD. We conclude that the tau protein may play a small role in the pathogenesis of PD and that biochemical characterization of this role may suggest opportunities for PD prophylaxis. © 2001 Movement Disorder Society.
- Subjects :
- Genetic Markers
Male
medicine.medical_specialty
Pathology
Parkinson's disease
Genotype
Tau protein
Synucleins
Nerve Tissue Proteins
tau Proteins
Gastroenterology
Progressive supranuclear palsy
Central nervous system disease
Gene Frequency
Internal medicine
medicine
Humans
Protein Isoforms
Allele
Alleles
Aged
biology
Parkinson Disease
Middle Aged
medicine.disease
Genotype frequency
Neurology
Case-Control Studies
biology.protein
Female
Neurology (clinical)
Tauopathy
Supranuclear Palsy, Progressive
Subjects
Details
- ISSN :
- 08853185
- Volume :
- 16
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Accession number :
- edsair.doi.dedup.....c3d33d33b89de9b620649fac05d9c0d4