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Distinct extracellular–matrix remodeling events precede symptoms of inflammation
- Source :
- Shimshoni, E, Adir, I, Afik, R, Solomonov, I, Shenoy, A, Adler, M, Puricelli, L, Sabino, F M R, Savickas, S, Mouhadeb, O, Gluck, N, Fishman, S, Werner, L, Salame, T-M, Shouval, D S, Varol, C, auf dem Keller, U, Podestà, A, Geiger, T, Milani, P, Alon, U & Sagi, I 2021, ' Distinct extracellular-matrix remodeling events precede symptoms of inflammation ', Matrix Biology, vol. 96, pp. 47-68 . https://doi.org/10.1016/j.matbio.2020.11.001, Matrix Biology
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Abstract
- Identification of early processes leading to complex tissue pathologies, such as inflammatory bowel diseases, poses a major scientific and clinical challenge that is imperative for improved diagnosis and treatment. Most studies of inflammation onset focus on cellular processes and signaling molecules, while overlooking the environment in which they take place, the continuously remodeled extracellular matrix. In this study, we used colitis models for investigating extracellular-matrix dynamics during disease onset, while treating the matrix as a complete and defined entity. Through the analysis of matrix structure, stiffness and composition, we unexpectedly revealed that even prior to the first clinical symptoms, the colon displays its own unique extracellular-matrix signature and found specific markers of clinical potential, which were also validated in human subjects. We also show that the emergence of this pre-symptomatic matrix is mediated by subclinical infiltration of immune cells bearing remodeling enzymes. Remarkably, whether the inflammation is chronic or acute, its matrix signature converges at pre-symptomatic states. We suggest that the existence of a pre-symptomatic extracellular-matrix is general and relevant to a wide range of diseases.
- Subjects :
- 0301 basic medicine
Male
Proteomics
Cell signaling
Inflammation
Extracellular matrix
Machine Learning
03 medical and health sciences
Mice
Piroxicam
0302 clinical medicine
Immune system
SDG 3 - Good Health and Well-being
medicine
Electron microscopy
Animals
Humans
Colitis
Molecular Biology
Subclinical infection
business.industry
Dextran Sulfate
medicine.disease
Prognosis
3. Good health
Extracellular Matrix
Interleukin-10
Disease Models, Animal
030104 developmental biology
030220 oncology & carcinogenesis
Case-Control Studies
Gene Knockdown Techniques
Immunology
Proteolysis
Colitis, Ulcerative
Female
medicine.symptom
business
Infiltration (medical)
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 0945053X
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- Matrix Biology
- Accession number :
- edsair.doi.dedup.....c3cee40f005ca1cacc9816b0b8414426
- Full Text :
- https://doi.org/10.1016/j.matbio.2020.11.001