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Long noncoding RNAs as diagnostic biomarkers for the early detection of digestive tract cancers: a systematic review and meta-analysis
- Source :
- Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva. 112(10)
- Publication Year :
- 2020
-
Abstract
- Background: long noncoding RNAs (lncRNAs) have attracted attention recently. However, many inconsistencies frequently appeared for the early diagnosis of digestive tract cancers (DTCs). We performed this meta-analysis to describe the diagnostic performance of lncRNAs in the discrimination of DTCs. Methods: data were extracted from PubMed, Web of Science, Embase, and Cochrane Library. Their quality was evaluated using the revised Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Such parameters as sensitivity and specificity were included for pooled analyses. The STATA 12.0 and Meta-Disc 1.4 software packages were used to perform the statistical analysis. Results: sixty-nine papers were included in this meta-analysis. The pooled analysis of DTCs showed that lncRNAs had a sensitivity of 0.78 and a specificity of 0.80. The area under the summary ROC curve (AUC) was 0.86. For gastric cancer (GC), the pooled sensitivity and specificity were 0.77 (95 % CI: 0.72-0.81) and 0.75 (95 % CI: 0.71-0.79), respectively, and the AUC was 0.83. For colorectal cancer (CRC), these three parameters were 0.82 (95 % CI: 0.76-0.86), 0.84 (95 % CI: 0.79-0.88), and 0.90, respectively. For esophageal cancer (EC) sensitivity was 0.74 (95 % CI: 0.67-0.80) and specificity reached 0.86 (95 % CI: 0.72-0.93), with an AUC of 0.82. Conclusions: LncRNAs show potential diagnostic value for discrimination between DTCs.
- Subjects :
- Oncology
medicine.medical_specialty
Colorectal cancer
MEDLINE
Cochrane Library
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Biomarkers, Tumor
Diagnostic biomarker
Humans
Early Detection of Cancer
Gastrointestinal Neoplasms
business.industry
Gastroenterology
Cancer
General Medicine
Esophageal cancer
medicine.disease
030220 oncology & carcinogenesis
Meta-analysis
030211 gastroenterology & hepatology
Digestive tract
RNA, Long Noncoding
business
Subjects
Details
- ISSN :
- 11300108
- Volume :
- 112
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva
- Accession number :
- edsair.doi.dedup.....c3c5cc20a2d42c283916a2c28f5a9498