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Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder
- Source :
- The Million Veteran Program, Post Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium 2022, ' Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder ', Psychological Medicine, vol. 52, no. 16, pp. 3975-3984 . https://doi.org/10.1017/S0033291721000830, Mundy, J, Hübel, C, Gelernter, J, Levey, D, Murray, R M, Skelton, M, Stein, M B, Vassos, E, Breen, G, Coleman, J R I & Million Veteran Program, Post Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium 2021, ' Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder ', Psychological Medicine, vol. 52, no. 16, pp. 1-10 . https://doi.org/10.1017/S0033291721000830, Psychological Medicine, 52(16), 3975-3984. Cambridge University Press
- Publication Year :
- 2022
-
Abstract
- BackgroundPosttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are commonly reported co-occurring mental health consequences of psychological trauma exposure. The disorders have high genetic overlap. Trauma is a complex phenotype but research suggests that trauma sensitivity has a heritable basis. We investigated whether sensitivity to trauma in those with MDD reflects a similar genetic component in those with PTSD.MethodsGenetic correlations between PTSD and MDD in individuals reporting trauma and MDD in individuals not reporting trauma were estimated, as well as with recurrent MDD and single-episode MDD, using genome-wide association study (GWAS) summary statistics. Genetic correlations were replicated using PTSD data from the Psychiatric Genomics Consortium and the Million Veteran Program. Polygenic risk scores were generated in UK Biobank participants who met the criteria for lifetime MDD (N = 29 471). We investigated whether genetic loading for PTSD was associated with reporting trauma in these individuals.ResultsGenetic loading for PTSD was significantly associated with reporting trauma in individuals with MDD [OR 1.04 (95% CI 1.01–1.07), Empirical-p = 0.02]. PTSD was significantly more genetically correlated with recurrent MDD than with MDD in individuals not reporting trauma (rg differences = ~0.2, p < 0.008). Participants who had experienced recurrent MDD reported significantly higher rates of trauma than participants who had experienced single-episode MDD (χ2 > 166, p < 0.001)ConclusionsOur findings point towards the existence of genetic variants associated with trauma sensitivity that might be shared between PTSD and MDD, although replication with better powered GWAS is needed. Our findings corroborate previous research highlighting trauma exposure as a key risk factor for recurrent MDD.
- Subjects :
- Genetic correlations
Genome-wide association study
Major depressive disorder
Lower risk
behavioral disciplines and activities
03 medical and health sciences
0302 clinical medicine
Psychological trauma
mental disorders
Genetics
medicine
Risk factor
Genetic risk
Applied Psychology
business.industry
Posttraumatic stress disorder
medicine.disease
Mental health
Biobank
030227 psychiatry
Psychiatry and Mental health
Polygenic risk scores
Posttraumatic stress
Polygenic risk score
business
030217 neurology & neurosurgery
Clinical psychology
Subjects
Details
- Language :
- English
- ISSN :
- 00332917
- Database :
- OpenAIRE
- Journal :
- The Million Veteran Program, Post Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium 2022, ' Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder ', Psychological Medicine, vol. 52, no. 16, pp. 3975-3984 . https://doi.org/10.1017/S0033291721000830, Mundy, J, Hübel, C, Gelernter, J, Levey, D, Murray, R M, Skelton, M, Stein, M B, Vassos, E, Breen, G, Coleman, J R I & Million Veteran Program, Post Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium 2021, ' Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder ', Psychological Medicine, vol. 52, no. 16, pp. 1-10 . https://doi.org/10.1017/S0033291721000830, Psychological Medicine, 52(16), 3975-3984. Cambridge University Press
- Accession number :
- edsair.doi.dedup.....c3aa994fb109f0fecb6e0854898e594c