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Primary tumor excision in stage IV breast cancer at diagnosis without influence on survival: a retrospective analysis and review of the literature
- Source :
- Onkologie. 34(11)
- Publication Year :
- 2011
-
Abstract
- Patients with synchronous metastastic breast cancer and intact primary tumor traditionally undergo systemic treatment. Surgical intervention at the primary site is typically reserved for palliation and often replaceable by radiation. Nevertheless, local surgery in metastatic breast cancer has become an issue of great controversy since retrospective studies published during the recent years suggested a slight benefit from an operative procedure. We evaluated the effect of surgery on long-term survival and progression-free survival in synchronous stage IV breast cancer.We retrospectively reviewed the records of all breast cancer patients treated at our institution between 1986 and 2007. Information recorded for each patient included age, tumor characteristics, metastasis characteristics, therapy, progression-free survival, and overall survival. Survival data were compared between surgical and nonsurgical patients.61 patients with synchronous metastastic breast cancer and intact primary tumor were analyzed. 26 patients (43%) received no primary site surgery and 35 (57%) patients had surgery. Overall survival and progression-free survival determined via the Kaplan-Meier method showed no significant difference between the surgery and the non-surgery group.In patients with metastatic breast cancer, the operation of the primary tumor did not influence overall survival or progression-free survival.
- Subjects :
- Oncology
Adult
Cancer Research
medicine.medical_specialty
Breast Neoplasms
Risk Assessment
Disease-Free Survival
Metastasis
Breast cancer
Risk Factors
Internal medicine
Germany
medicine
Retrospective analysis
Prevalence
Humans
Prospective Studies
Prospective cohort study
Survival rate
Survival analysis
Mastectomy
Aged
Neoplasm Staging
Aged, 80 and over
business.industry
Carcinoma
Hematology
General Medicine
Middle Aged
medicine.disease
Prognosis
Primary tumor
Survival Analysis
Survival Rate
Treatment Outcome
Female
Stage iv
business
Subjects
Details
- ISSN :
- 14230240
- Volume :
- 34
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Onkologie
- Accession number :
- edsair.doi.dedup.....c391386d10e7f8e49d9e975543367f06