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Chronic dantrolene treatment attenuates cardiac dysfunction and reduces atrial fibrillation inducibility in a rat myocardial infarction heart failure modelKey Findings
- Source :
- Heart Rhythm O2, Vol 1, Iss 2, Pp 126-135 (2020), Heart Rhythm O2
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Background: Cardiac ryanodine receptor 2 (RyR2) dysfunction and elevated diastolic Ca2+ leak have been linked to arrhythmogenesis not only in inherited arrhythmia syndromes but also in acquired forms of heart disease including heart failure (HF) and atrial fibrillation (AF). Thus, stabilizing RyR2 may exert therapeutic effects in these conditions. Objective: The purpose of this study was to investigate the effects of stabilizing RyR2 with chronic dantrolene treatment on HF development and AF inducibility in a myocardial infarction (MI)–induced HF model in rats. Methods: MI was induced in adult Sprague-Dawley rats by ligation of the left anterior descending coronary artery. Two weeks after MI surgery, rats with large MI (≥40%) were randomly assigned to MI-vehicle (n = 14) or MI-dantrolene (10 mg/kg/d; n = 13) groups. Sham-surgery rats (n = 7) served as controls. Results: Compared to the MI-vehicle group, 4-week dantrolene treatment significantly improved cardiac function, with increased left ventricular (LV) fractional shortening (19.48% ± 3.61% vs 15.43% ± 2.65%; P
- Subjects :
- Cardiac function curve
medicine.medical_specialty
Cardiac ryanodine receptor
Heart disease
business.industry
Diastole
Atrial fibrillation
Heart failure
Ryanodine receptor stabilizer
medicine.disease
Ryanodine receptor 2
Dantrolene
Experimental
Internal medicine
RC666-701
cardiovascular system
medicine
Cardiology
Diseases of the circulatory (Cardiovascular) system
Myocardial infarction
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 26665018
- Volume :
- 1
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Heart Rhythm O2
- Accession number :
- edsair.doi.dedup.....c37c1ff2fc1e4bd673cf7b6220de5d7b