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Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019), Nature Communications
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Despite the efficacy of current starvation therapies, they are often associated with some intrinsic drawbacks such as poor persistence, facile tumor metastasis and recurrence. Herein, we establish an extravascular gelation shrinkage-derived internal stress strategy for squeezing and narrowing blood vessels, occluding blood & nutrition supply, reducing vascular density, inducing hypoxia and apoptosis and eventually realizing starvation therapy of malignancies. To this end, a biocompatible composite hydrogel consisting of gold nanorods (GNRs) and thermal-sensitive hydrogel mixture was engineered, wherein GRNs can strengthen the structural property of hydrogel mixture and enable robust gelation shrinkage-induced internal stresses. Systematic experiments demonstrate that this starvation therapy can suppress the growths of PANC-1 pancreatic cancer and 4T1 breast cancer. More significantly, this starvation strategy can suppress tumor metastasis and tumor recurrence via reducing vascular density and blood supply and occluding tumor migration passages, which thus provides a promising avenue to comprehensive cancer therapy.<br />The efficacy of tumour starvation therapy is limited by lack of persistent tumour suppression, tumour metastasis and recurrence. Here, the authors report biocompatible gold nanorods and thermal-sensitive hydrogel to promote narrowing of blood vessels and show this to reduce tumour growth and metastasis.
- Subjects :
- Acrylic Resins
General Physics and Astronomy
02 engineering and technology
01 natural sciences
Metastasis
Rats, Sprague-Dawley
lcsh:Science
Cancer
Starvation
Nanotubes
Multidisciplinary
Chemistry
Hydrogels
021001 nanoscience & nanotechnology
Female
Laser Therapy
medicine.symptom
Rheology
0210 nano-technology
Biotechnology
Science
Mice, Nude
Antineoplastic Agents
Breast Neoplasms
010402 general chemistry
Article
General Biochemistry, Genetics and Molecular Biology
Biomaterials
Breast cancer
Cell Line, Tumor
Pancreatic cancer
medicine
Animals
Humans
General Chemistry
Structural property
Translational research
Hypoxia (medical)
medicine.disease
Xenograft Model Antitumor Assays
0104 chemical sciences
Pancreatic Neoplasms
Apoptosis
Cancer research
Blood Vessels
lcsh:Q
Gold
Neoplasm Recurrence, Local
Internal stress
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....c37bd30024503a769801eecd2c53bddf