Back to Search
Start Over
Hyperuricemia Predicts an Early Decline in Renal Function among Older People: A Community-Based Cohort Study
- Source :
- Scientific Reports, Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Publishing Group UK, 2019.
-
Abstract
- Whether elevated serum uric acid levels (SUA) predict renal dysfunction remains controversial in the elderly. Therefore, we investigated the association between SUA and early renal function decline defined as an estimated glomerular filtration rate (eGFR) reduction ≥30% over 2 years. From 2001 to 2010, we conducted a longitudinal cohort study comprising 44,078 participants aged ≥65 years in the Taipei City Elderly Health Examination Database. Participants were classified by 1-mg/dL increment of SUA. We used multivariable logistic and Cox regression analyses to compare the risk of early renal function decline in different SUA groups. Compared to the reference SUA group of 5.0–5.9 mg/dL, hyperuricemic participants had increased risks of eGFR decline, starting at SUA ≥6.0 mg/dL (adjusted odds ratio [aOR] = 1.21, 95% confidence interval [CI] = 1.00–1.45). The risk progressively elevated as SUA increased, with the highest in the SUA ≥10.0 mg/dL group (aOR = 3.20, CI = 2.39–4.28). Multivariable Cox regression further confirmed that hyperuricemia was 1.12-fold (CI = 1.03–1.22, SUA ≥6.0 mg/dL) to 1.6-fold (CI = 1.37–1.86, SUA ≥10.0 mg/dL) more likely to develop early eGFR decline. Hyperuricemia-associated increased risks for early eGFR decline were consistent across subgroup and sensitivity analyses. Collectively, SUA ≥6.0 mg/dL independently predicted early renal dysfunction with eGFR decline ≥30% over 2 years in older people.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Renal function
lcsh:Medicine
Hyperuricemia
Kidney
Kidney Function Tests
Models, Biological
Article
Cohort Studies
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Residence Characteristics
Risk Factors
Internal medicine
medicine
Humans
lcsh:Science
Aged
Proportional Hazards Models
Multidisciplinary
business.industry
Proportional hazards model
Incidence (epidemiology)
Incidence
lcsh:R
Odds ratio
medicine.disease
Confidence interval
Uric Acid
030104 developmental biology
chemistry
Uric acid
lcsh:Q
Female
business
030217 neurology & neurosurgery
Cohort study
Follow-Up Studies
Glomerular Filtration Rate
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....c371cd428a81124177a8342d98b90517