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Maximizing the potency of oxaliplatin coated nanoparticles with folic acid for modulating tumor progression in colorectal cancer
- Source :
- MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 120. ELSEVIER, Materials Science and Engineering: C
- Publication Year :
- 2021
-
Abstract
- One of the challenges of nanotechnology is to improve the efficacy of treatments for diseases, in order to reduce morbidity and mortality rates. Following this line of study, we made a nanoparticle formulation with a small size, uniform surfaces, and a satisfactory encapsulation coefficient as a target for colorectal cancer cells. The results of binding and uptake prove that using the target system with folic acid works: Using this system, cytotoxicity and cell death are increased when compared to using free oxaliplatin. The data show that the system maximized the efficiency of oxaliplatin in modulating tumor progression, increasing apoptosis and decreasing resistance to the drug. Thus, for the first time, our findings suggest that PLGA-PEG-FA increases the antitumor effectiveness of oxaliplatin by functioning as a facilitator of drug delivery in colorectal cancer.
- Subjects :
- Drug
Materials science
Folic acid
Colorectal cancer
media_common.quotation_subject
Drug delivery system
Bioengineering
Antineoplastic Agents
Apoptosis
02 engineering and technology
Drug resistance
010402 general chemistry
01 natural sciences
Polyethylene Glycols
Biomaterials
Cell Line, Tumor
medicine
Humans
Cytotoxicity
media_common
Drug Carriers
021001 nanoscience & nanotechnology
medicine.disease
0104 chemical sciences
3. Good health
Oxaliplatin
Mechanics of Materials
Tumor progression
Drug delivery
Cancer research
Nanoparticles
0210 nano-technology
Colorectal Neoplasms
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 120. ELSEVIER, Materials Science and Engineering: C
- Accession number :
- edsair.doi.dedup.....c370129abaf37d59b69e4eef0445cc84