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Twenty-Four-Hour Cardiovascular Effects of Electronic Cigarettes Compared With Cigarette Smoking in Dual Users
- Source :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
- Publication Year :
- 2020
-
Abstract
- Background Cardiovascular safety is an important consideration regarding the benefits versus risks of electronic cigarette use (EC) for public health. The single‐use cardiovascular effects of EC have been well studied but may not reflect effects of ad libitum use throughout the day. We aimed to compare the circadian hemodynamic effects as well as 24‐hour biomarkers of oxidative stress, and platelet aggregation and inflammation, with ad libitum cigarette smoking (CS) versus EC versus no tobacco product use. Methods and Results Thirty‐six healthy dual CS and EC users participated in a crossover study in a confined research setting. Circadian heart rate, blood pressure and plasma nicotine levels, 24‐hour urinary catecholamines, 8‐isoprostane and 11‐dehydro‐thromboxane B2, and plasma interleukin‐6 and interleukin‐8 were compared in CS, EC, and no nicotine conditions. Over 24 hours, and during daytime, heart rate and blood pressure were higher in CS and EC compared with no tobacco product conditions ( P P Conclusions CS and EC had similar 24‐hour patterns of hemodynamic effects compared with no tobacco product, with a higher average heart rate with CS versus EC, and similar effects on biomarkers of inflammation. EC may pose some cardiovascular risk, particularly to smokers with underlying cardiovascular disease, but may also provide a harm reduction opportunity for smokers willing to switch entirely to EC. Registration URL: https://www.clinicaltrials.gov ; Unique Identifier: NCT02470754.
- Subjects :
- Adult
Male
medicine.medical_specialty
Nicotine
Platelet Aggregation
Urinary system
Blood Pressure
030204 cardiovascular system & hematology
Electronic Nicotine Delivery Systems
medicine.disease_cause
tobacco
Cigarette Smoking
03 medical and health sciences
0302 clinical medicine
Catecholamines
Cigarette smoking
Heart Rate
Internal medicine
Heart rate
Clinical Studies
medicine
Humans
030212 general & internal medicine
Circadian rhythm
Preventive Cardiology
Original Research
Inflammation
Cross-Over Studies
business.industry
Vaping
Hemodynamics
biomarkers
Middle Aged
Crossover study
Circadian Rhythm
Oxidative Stress
Blood pressure
electronic cigarettes
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Oxidative stress
medicine.drug
Subjects
Details
- ISSN :
- 20479980
- Volume :
- 9
- Issue :
- 23
- Database :
- OpenAIRE
- Journal :
- Journal of the American Heart Association
- Accession number :
- edsair.doi.dedup.....c3676bbaf9378bd527c3a23a10d5875b