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Translational Genomics in Neurocritical Care: a Review
- Source :
- Neurotherapeutics
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Translational genomics represents a broad field of study that combines genome and transcriptome-wide studies in humans and model systems to refine our understanding of human biology and ultimately identify new ways to treat and prevent disease. The approaches to translational genomics can be broadly grouped into two methodologies, forward and reverse genomic translation. Traditional (forward) genomic translation begins with model systems and aims at using unbiased genetic associations in these models to derive insight into biological mechanisms that may also be relevant in human disease. Reverse genomic translation begins with observations made through human genomic studies and refines these observations through follow-up studies using model systems. The ultimate goal of these approaches is to clarify intervenable processes as targets for therapeutic development. In this review, we describe some of the approaches being taken to apply translational genomics to the study of diseases commonly encountered in the neurocritical care setting, including hemorrhagic and ischemic stroke, traumatic brain injury, subarachnoid hemorrhage, and status epilepticus, utilizing both forward and reverse genomic translational techniques. Further, we highlight approaches in the field that could be applied in neurocritical care to improve our ability to identify new treatment modalities as well as to provide important information to patients about risk and prognosis. Electronic supplementary material The online version of this article (10.1007/s13311-020-00838-1) contains supplementary material, which is available to authorized users.
- Subjects :
- 0301 basic medicine
Translation
Critical Care
Computer science
Genomics
Review
Disease
Computational biology
Translational Research, Biomedical
03 medical and health sciences
0302 clinical medicine
Human disease
TBI
Neurocritical care
Genetics
Animals
Humans
Pharmacology (medical)
Translational genomics
Pharmacology
Brain Diseases
Neurointensive care
Stroke
030104 developmental biology
Neurology
Treatment modality
Ischemic stroke
Neurology (clinical)
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18787479 and 19337213
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Neurotherapeutics
- Accession number :
- edsair.doi.dedup.....c3571a337d070922d1b8006b8ae25c72