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Association between Renal Dysfunction and the Mixed Plaque of Coronary Artery on Computed Tomographic Angiography
- Source :
- The Tohoku Journal of Experimental Medicine. 225:171-177
- Publication Year :
- 2011
- Publisher :
- Tohoku University Medical Press, 2011.
-
Abstract
- Coronary artery plaque is related to development of coronary artery disease (CAD), and chronic kidney disease is associated with CAD. However, the association of renal dysfunction (RD) with coronary artery plaque characteristics has not been fully elucidated. We evaluated the association between RD and coronary artery plaque characteristics in patients with suspected CAD, who underwent multislice computed tomographic angiography (CTA). A total of 918 patients were classified into 4 groups: group with no plaque (NP) (48.9%), group with calcified plaque (CP) (16.0%), group with noncalcified plaque (NCP) (22.4%), and group with mixed plaque (MP) (12.7%). NCP is considered as rupture-prone soft plaque, and CP as more stable lesion. The mean of estimated glomerular filtration rate (eGFR) was 82.5 ± 15.4 mL/min/1.73m2, and the prevalence of RD (defined as eGFR < 60 mL/min/1.73m2) was 6.3%. The prevalence of RD was 3.3% in the NP group, 10.2% in the CP group, 5.3% in the NCP group, and 14.5% in the MP group (P < 0.001 by ANOVA tests). The adjusted odds ratio for RD was 3.38 (95% confidence interval, 1.27 - 9.04) for the MP group, compared with the NP group. The presence of RD showed an independent association with the MP counts (r = 0.155, P < 0.001); however, there was no association between RD and other plaque characteristics. In conclusion, RD is associated with MP rather than CP or NCP, compared with NP, which may reflect one of the developmental processes of CAD in patients with RD.
- Subjects :
- medicine.medical_specialty
Renal function
Coronary Artery Disease
Coronary Angiography
General Biochemistry, Genetics and Molecular Biology
Lesion
Coronary artery disease
Internal medicine
Multidetector Computed Tomography
Odds Ratio
medicine
Humans
Multislice
Analysis of Variance
business.industry
General Medicine
Odds ratio
medicine.disease
Plaque, Atherosclerotic
Confidence interval
medicine.anatomical_structure
Cardiology
Kidney Failure, Chronic
medicine.symptom
business
Glomerular Filtration Rate
Artery
Kidney disease
Subjects
Details
- ISSN :
- 13493329 and 00408727
- Volume :
- 225
- Database :
- OpenAIRE
- Journal :
- The Tohoku Journal of Experimental Medicine
- Accession number :
- edsair.doi.dedup.....c34ecc7e9cafbc1bc36fe32af84d1005