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Efficient Class I Major Histocompatibility Complex Down-Regulation by Simian Immunodeficiency Virus Nef Is Associated with a Strong Selective Advantage in Infected Rhesus Macaques
- Source :
- Journal of Virology. 75:10532-10536
- Publication Year :
- 2001
- Publisher :
- American Society for Microbiology, 2001.
-
Abstract
- Substitution of Y223F disrupts the ability of simian immunodeficiency virus (SIV) Nef to down-modulate major histocompatibility complex (MHC) class I from the cell surface but has no effect on other Nef functions, such as down-regulation of CD4, CD28, and CD3 cell surface expression or stimulation of viral replication and enhancement of virion infectivity. Inoculation of three rhesus macaques with the SIVmac239 Y223F-Nef variant revealed that this point mutation consistently reverts and that Nef activity in MHC class I down-modulation is fully restored within 4 weeks after infection. Our results demonstrate a strong selective pressure for a tyrosine at amino acid position 223 in SIV Nef, and they constitute evidence that Nef-mediated MHC class I down-regulation provides a selective advantage for viral replication in vivo.
- Subjects :
- viruses
CD3
Immunology
Simian Acquired Immunodeficiency Syndrome
Down-Regulation
Biology
Virus Replication
medicine.disease_cause
Major histocompatibility complex
Microbiology
Gene Products, nef
Structure-Activity Relationship
Virology
MHC class I
medicine
Animals
Infectivity
Point mutation
Histocompatibility Antigens Class I
virus diseases
CD28
Simian immunodeficiency virus
Macaca mulatta
Viral replication
Insect Science
biology.protein
Pathogenesis and Immunity
Simian Immunodeficiency Virus
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....c34aba6f617525c6cb7037f5cf857392
- Full Text :
- https://doi.org/10.1128/jvi.75.21.10532-10536.2001