Back to Search
Start Over
Thrombocytopenia in falciparum malaria is associated with high concentrations of IL-10
- Source :
- Europe PubMed Central
- Publication Year :
- 2016
-
Abstract
- Over the last decade, a number of observations have suggested that platelets may play a role in the pathophysiology of severe malaria. However, somewhat paradoxically, thrombocytopenia is not associated clearly with outcome. We studied the relationship between thrombocytopenia and cytokines in Kenyan children with severe malaria and showed that thrombocytopenia (platelet count < 150 x 10(9)/L) strongly correlates with high levels of interleukin (IL)-10. Several studies have shown that high levels of IL-10 are associated with a favorable outcome in severe malaria. Taken together, these data suggest why thrombocytopenia has a complex relationship with severe disease and suggest one mechanism whereby IL-10 may modify the outcome of severe disease.
- Subjects :
- Male
medicine.medical_specialty
macromolecular substances
Virology
parasitic diseases
medicine
Humans
Platelet
Favorable outcome
Malaria, Falciparum
Child
biology
musculoskeletal, neural, and ocular physiology
Interleukin
Infant
Plasmodium falciparum
biology.organism_classification
medicine.disease
Thrombocytopenia
Pathophysiology
Interleukin-10
Interleukin 10
Infectious Diseases
nervous system
Child, Preschool
Immunology
Tropical medicine
Parasitology
Female
Malaria
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Europe PubMed Central
- Accession number :
- edsair.doi.dedup.....c33f5d8da78fc1c174a821209624f239