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Opiate detoxification of methadone maintenance patients using lefetamine, clonidine and buprenorphine
- Source :
- Drug and Alcohol Dependence. 36:139-145
- Publication Year :
- 1994
- Publisher :
- Elsevier BV, 1994.
-
Abstract
- Thirty-nine methadone maintenance patients were included in a 9-day, double blind, randomized, inpatient detoxification trial. Methadone was tapered to 10 mg/day and then patients were assigned to one of these 3 protocols: clonidine (0.3-0.9 mgday), lefetamine (60–240 mg/day), buprenorphine (0.15-0.9 mg/day). Buprenorphine treatment was significantly superior to clonidine and to lefetamine (F = 3.96 df = 2, 29 P < 0.05) in controlling objective, subjective and psychological withdrawal symptomatology. Clonidine was more effective than lefetamine in suppressing withdrawal in the first 3 days of treatment (day 3: F = 4.10 df = 2, 30 P < 0.05), and this trend was apparent on the objective and psychological items. In addition to evaluations of the efficacy of the single drugs used, the study showed that tapering methadone to low doses before entering the pharmacologically assisted discontinuation phase was clinically acceptable in detoxification from long-term methadone treatment.
- Subjects :
- Adult
Male
Methadone maintenance
Lefetamine
Toxicology
Clonidine
Drug Administration Schedule
Patient Admission
Double-Blind Method
Buprenorphine
Methadone detoxification
Pharmacology
Psychiatry and Mental Health
Pharmacology (medical)
Detoxification
Phenethylamines
medicine
Humans
Neurologic Examination
Dose-Response Relationship, Drug
Heroin Dependence
business.industry
Opioid-Related Disorders
Substance Withdrawal Syndrome
Discontinuation
Analgesics, Opioid
Psychiatry and Mental health
Anesthesia
Female
Opiate
business
Methadone
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 03768716
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Drug and Alcohol Dependence
- Accession number :
- edsair.doi.dedup.....c33da95e37532872375cf473c2b6fb66