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Hygromycin A derivatives isolated from Streptomyces sp. PC-22 in the rhizosphere soil of Pulsatilla chinensis

Authors :
Xiaoqian, Ding
Tianjie, Yuan
Weiwei, Chen
Xiachang, Wang
Yiwen, Chu
Xiao, Liu
Yang, Hu
Lihong, Hu
Source :
The Journal of Antibiotics. 75:176-180
Publication Year :
2022
Publisher :
Springer Science and Business Media LLC, 2022.

Abstract

On the basis of the one strain-many compounds (OSMAC) strategy, two new hygromycin A derivatives (3, 4), together with six known compounds were isolated from a medicinal plant inter rhizospheric Streptomyces in Pulsatilla chinensis. The structures of 3 and 4 were elucidated using NMR and HRESIMS analyses. A plausible biosynthetic pathway for these compounds was discussed. All the compounds were evaluated for their antimicrobial and cytotoxic activities. Compound 5 exhibited potent inhibitory activity against S. aureus and B. subtilis with the MICs of 16 and 8 μg ml

Details

ISSN :
18811469 and 00218820
Volume :
75
Database :
OpenAIRE
Journal :
The Journal of Antibiotics
Accession number :
edsair.doi.dedup.....c33254aa0f633debb9b51c06b42bde4c
Full Text :
https://doi.org/10.1038/s41429-022-00506-w