Back to Search
Start Over
Associations Between Tenofovir Diphosphate in Dried Blood Spots, Impaired Physical Function, and Fracture Risk
- Source :
- Open Forum Infectious Diseases
- Publication Year :
- 2020
-
Abstract
- Background In this study, we evaluate associations between cumulative antiretroviral adherence/exposure, quantified using tenofovir diphosphate (TFV-DP) in dried blood spots (DBS), and human immunodeficiency virus (HIV)-related aging factors. Methods This is a cross-sectional analysis of younger (ages 18–35) and older (ages ≥60) persons with HIV (PWH) taking TFV disoproxil fumarate. Tenofovir diphosphate concentrations were quantified in DBS. Linear and logistic regression models were used to evaluate associations between TFV-DP and bone mineral density (BMD), physical function, frailty, and falls. Results Forty-five PWH were enrolled (23 younger, 22 older). Every 500 fmol/punch (equivalent to an increase in ~2 doses/week) increase in TFV-DP was associated with decreased hip BMD (−0.021 g/cm2; 95% confidence interval [CI], −0.040 to −0.002; P = .03). Adjusting for total fat mass, every 500 fmol/punch increase in TFV-DP was associated with higher odds of Short Physical Performance Battery impairment (score ≤10; adjusted odds ratio [OR], 1.6; 95% CI, 1.0–2.5; P = .04). Every 500 fmol/punch increase in TFV-DP was associated with slower 400-meter walk time (14.8 seconds; 95% CI, 3.8–25.8; P = .01) and remained significant after adjusting for age, lean body mass, body mass index (BMI), and fat mass (all P ≤ .01). Every 500 fmol/punch increase in TFV-DP was associated with higher odds of reporting a fall in the prior 6 months (OR, 1.8; 95% CI, 1.1–2.8; P = .02); this remained significant after adjusting for age, lean body mass, BMI, and total fat mass (all P<br />The associations between tenofovir diphosphate (TFV-DP) in dried blood spots (DBS) and human immunodeficiency virus (HIV)-related aging factors was evaluated. Higher TFV-DP levels were found to be associated with impaired physical function and fracture risk.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
030106 microbiology
Physical function
Logistic regression
Gastroenterology
Odds
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Major Article
030212 general & internal medicine
Bone mineral
business.industry
aging
HIV
Odds ratio
Confidence interval
Editor's Choice
Infectious Diseases
AcademicSubjects/MED00290
Oncology
tenofovir diphosphate
Lean body mass
dried blood spots
business
bone mineral density
Body mass index
Subjects
Details
- ISSN :
- 23288957
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Open forum infectious diseases
- Accession number :
- edsair.doi.dedup.....c31e023311a4a8d2d25a9ffe5c9d21c6