Back to Search
Start Over
The role of mRNA in the development, diagnosis, treatment and prognosis of neural tumors
- Source :
- Molecular Cancer, Molecular Cancer, Vol 20, Iss 1, Pp 1-16 (2021)
- Publication Year :
- 2021
- Publisher :
- BioMed Central, 2021.
-
Abstract
- Neural tumors can generally be divided into central nervous system tumors and peripheral nervous tumors. Because this type of tumor is located in the nerve, even benign tumors are often difficult to remove by surgery. In addition, the majority of neural tumors are malignant, and it is particular the same for the central nervous system tumors. Even treated with the means such as chemotherapy and radiotherapy, they are also difficult to completely cure. In recent years, an increasingly number of studies have focused on the use of mRNA to treat tumors, representing an emerging gene therapy. The use of mRNA can use the expression of some functional proteins for the treatment of genetic disorders or tissue repair, and it can also be applied to immunotherapy through the expression of antigens, antibodies or receptors. Therefore, although these therapies are not fully-fledged enough, they have a broad research prospect. In addition, there are many ways to treat tumors using mRNA vaccines and exosomes carrying mRNA, which have drawn much attention. In this study, we reviewed the current research on the role of mRNA in the development, diagnosis, treatment and prognosis of neural tumors, and examine the future research prospects of mRNA in neural tumors and the opportunities and challenges that will arise in the future application of clinical treatment.
- Subjects :
- 0301 basic medicine
Cancer Research
Genetic enhancement
medicine.medical_treatment
mRNA
Central nervous system
Nervous System Neoplasms
Review
Biology
Bioinformatics
Exosomes
lcsh:RC254-282
Cancer Vaccines
RNA Transport
Epigenesis, Genetic
Diagnosis, Differential
03 medical and health sciences
0302 clinical medicine
Antigen
medicine
Biomarkers, Tumor
Animals
Humans
RNA, Messenger
Regulation of gene expression
Chemotherapy
Neural tumor
Disease Management
Immunotherapy
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
Combined Modality Therapy
Microvesicles
Gene regulation
Radiation therapy
Gene Expression Regulation, Neoplastic
030104 developmental biology
medicine.anatomical_structure
Cell Transformation, Neoplastic
Oncology
Molecular Diagnostic Techniques
Organ Specificity
030220 oncology & carcinogenesis
Molecular Medicine
Disease Susceptibility
Tumor therapy
Subjects
Details
- Language :
- English
- ISSN :
- 14764598
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Molecular Cancer
- Accession number :
- edsair.doi.dedup.....c312e64abf5811cd37af023f88ea79f4