CORRELATION OF HISTOPATHOLOGY WITH CLINICAL RESULTS FOLLOWING RADIATION THERAPY FOR CARCINOMA OF THE CERVIX

Survival rates by stage and patterns and incidence of treatment failure were analyzed in a group of patients with squamous cell carcinoma of the cervix who were treated with supervoltage radiation and intracavitary radium. Histologic grading was done by the Reagan-Wentz method. Clinical information was correlated with the pathologic findings to determine if differential radioresistance or decreased radiocurability exists by grade.Five year survival rates by stage in the present series are equal to those of an M. D. Anderson Hospital series. No evidence was found to support the concept of differential radiocurability by histologic grade. In particular no local failures occurred at any stage of disease after "curative" treatment in the small cell carcinomas—either the "pure" or "any component" groups. Failures were related to clinical stage or bulk of disease. Modern radiotherapeutic techniques may in fact overcome any tendency for the differences in survival rates found between histologic grades in previou...