Back to Search
Start Over
Pneumonia-SpecificEscherichia coliwith Distinct Phylogenetic and Virulence Profiles, France, 2012–2014
- Source :
- Emerging Infectious Diseases, Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2019, 25 (4), pp.710-718. ⟨10.3201/eid2504.180944⟩, Emerging Infectious Diseases, Vol 25, Iss 4, Pp 710-718 (2019)
- Publication Year :
- 2019
- Publisher :
- Centers for Disease Control and Prevention (CDC), 2019.
-
Abstract
- International audience; In a prospective, nationwide study in France of Escherichia coli responsible for pneumonia in patients receiving mechanical ventilation, we determined E. coli antimicrobial susceptibility, phylotype, O-type, and virulence factor gene content. We compared 260 isolates with those of 2 published collections containing commensal and bacteremia isolates. The preponderant phylogenetic group was B2 (59.6%), and the predominant sequence type complex (STc) was STc73. STc127 and STc141 were overrepresented and STc95 underrepresented in pneumonia isolates compared with bacteremia isolates. Pneumonia isolates carried higher proportions of virulence genes sfa/foc, papGIII, hlyC, cnf1, and iroN compared with bacteremia isolates. Virulence factor gene content and antimicrobial drug resistance were higher in pneumonia than in commensal isolates. Genomic and phylogenetic characteristics of E. coli pneumonia isolates from critically ill patients indicate that they belong to the extraintestinal pathogenic E. coli pathovar but have distinguishable lung-specific traits.
- Subjects :
- 0301 basic medicine
Epidemiology
virulence factors
lcsh:Medicine
medicine.disease_cause
Virulence factor
Nosocomial infection
0302 clinical medicine
Public Health Surveillance
bacteria
Escherichia coli Infections
Phylogeny
Phylotype
Virulence
Phylogenetic tree
Anti-Bacterial Agents
3. Good health
Infectious Diseases
Pathovar
France
Pneumonia (non-human)
Microbiology (medical)
030231 tropical medicine
030106 microbiology
Microbial Sensitivity Tests
Biology
Serogroup
History, 21st Century
lcsh:Infectious and parasitic diseases
Microbiology
respiratory infections
ventilator-associated pneumonia
03 medical and health sciences
Antibiotic resistance
Drug Resistance, Bacterial
Pneumonia, Bacterial
Escherichia coli
medicine
pneumonia
Humans
lcsh:RC109-216
antimicrobial resistance
Research
lcsh:R
biology.organism_classification
medicine.disease
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Molecular Typing
Pneumonia-Specific Escherichia coli with Distinct Phylogenetic and Virulence Profiles, France, 2012–2014
Genes, Bacterial
Subjects
Details
- ISSN :
- 10806059 and 10806040
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Emerging Infectious Diseases
- Accession number :
- edsair.doi.dedup.....c2d9433278e57e42bd80b80ddc99f40d