Back to Search
Start Over
A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up
- Source :
- Pathology - Research and Practice. 207:664-669
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- A 19-year-old woman was admitted to the hospital with a complaint of right wrist pain. A plain radiograph showed an osteolytic lesion in the right distal radius. Surgical treatment with curettage and bone grafting was performed under the clinical diagnosis of a giant-cell tumor. However, local recurrence was noticed 6 months after the treatment, and the curettage and bone graft were performed again. The histology of the recurrent lesion revealed a malignant giant-cell tumor that was entirely composed of highly atypical stromal cells and tumor giant cells. After a retrospective review of the primary lesion, it was found to also contain a small focus of pleomorphic cells within the conventional giant-cell tumor. Immunohistochemical and genetic analysis revealed p53 overexpression in the tumor giant cells and loss of heterozygosity of p53 gene only in the recurrent tumor; thus, a diagnosis of secondary malignant giant-cell tumor was finally made. The patient underwent systemic chemotherapy along with curettage and cryosurgery using liquid nitrogen. It is now 1 year and 4 months after the last treatment, and the patient is well and alive with no evidence of the disease. Identification of p53 genetic alteration may help in diagnosing malignant giant-cell tumor.
- Subjects :
- Pathology
medicine.medical_specialty
Stromal cell
medicine.medical_treatment
DNA Mutational Analysis
Molecular Sequence Data
Loss of Heterozygosity
Bone Neoplasms
Laser Capture Microdissection
Bone grafting
Polymerase Chain Reaction
Cryosurgery
Pathology and Forensic Medicine
Loss of heterozygosity
Young Adult
medicine
Humans
Giant Cell Tumor of Bone
Base Sequence
business.industry
Histology
Cell Biology
Immunohistochemistry
Curettage
Cell Transformation, Neoplastic
Giant cell
Female
Neoplasm Recurrence, Local
Tumor Suppressor Protein p53
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 03440338
- Volume :
- 207
- Database :
- OpenAIRE
- Journal :
- Pathology - Research and Practice
- Accession number :
- edsair.doi.dedup.....c2d37da19f1dcbe041310bb9d5bb046c