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Tissue factor pathway inhibitor expression in human crescentic glomerulonephritis
- Source :
- Kidney International. 55:1311-1318
- Publication Year :
- 1999
- Publisher :
- Elsevier BV, 1999.
-
Abstract
- Tissue factor pathway inhibitor expression in human crescentic glomerulonephritis. Background Tissue factor (TF) pathway inhibitor (TFPI), the major endogenous inhibitor of extrinsic coagulation pathway activation, protects renal function in experimental crescentic glomerulonephritis (GN). Its glomerular expression and relationship to TF expression and fibrin deposition in human crescentic GN have not been reported. Methods Glomerular TFPI, TF, and fibrin-related antigen (FRA) expression were correlated in renal biopsies from 11 patients with crescentic GN. Biopsies from 11 patients with thin basement membrane disease and two normal kidneys were used as controls. Results TFPI was undetectable in control glomeruli but was detectable in interstitial microvessels. In crescentic biopsies, TFPI was detected in cellular crescents and was more prominent in fibrous/fibrocellular crescents, indicating a correlation with the chronicity of crescentic lesions. TFPI appeared to be associated with macrophages but not endothelial or epithelial cells. TFPI was generally undetectable in regions of the glomerular tuft with minimal damage. In contrast, TF and FRA were strongly expressed in regions of minimal injury, as well as in more advanced proliferative and necrotizing lesions. Despite prominent TF expression, FRA was less prominent in fibrous/fibrocellular crescents in which TFPI expression was maximal. Conclusions These data suggest that TFPI is strongly expressed in the later stages of crescent formation and is inversely correlated with the presence of FRA in human crescentic GN. This late induction of TFPI may inhibit TF activity and favor reduced fibrin deposition in the chronic stages of crescent formation.
- Subjects :
- Adult
Male
crescents
Pathology
medicine.medical_specialty
renal injury
Renal glomerulus
Biopsy
Lipoproteins
Kidney Glomerulus
urologic and male genital diseases
Basement Membrane
Fibrin
Thromboplastin
Fibrin Fibrinogen Degradation Products
Tissue factor
Glomerulonephritis
Tissue factor pathway inhibitor
Internal medicine
medicine
Humans
fibrin
Antigens
coagulation
Basement membrane
Kidney
biology
urogenital system
Chemistry
food and beverages
Middle Aged
medicine.disease
female genital diseases and pregnancy complications
Arterioles
pro-coagulant activity
medicine.anatomical_structure
Endocrinology
Nephrology
embryonic structures
Disease Progression
biology.protein
Female
proteinuria
Subjects
Details
- ISSN :
- 00852538
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Kidney International
- Accession number :
- edsair.doi.dedup.....c2c39e3643fd09bda78c0654a768f768