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The COX-2-1195AA Genotype Is Associated with Diffuse-Type Gastric Cancer in Korea
- Source :
- Gut and Liver
- Publication Year :
- 2012
- Publisher :
- The Korean Society of Gastroenterology; the Korean Society of Gastrointestinal Endoscopy; the Korean Association for the Study of the Liver; the Korean Society of Neurogastroenterology and Motility; Korean Association for the Study of Intestinal Diseases; Korean College of Helicobacter and Upper Gastrointestinal Research; Korean Pancreatobiliary Association; Korean Society of Gastrointestinal Cancer, 2012.
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Abstract
- Background/Aims: The potential role of the cyclooxygenase (COX)-2 polymorphism has been reported in relation to the risk of gastrointestinal tract malignancies. Therefore, we investigated whether COX-2 polymorphisms are associated with the risk of gastric cancer (GC) in Korea, one of the areas with a high prevalence of this condition. Methods: We evaluated the genotypic frequencies of COX-2-765 and -1195 in 100 peptic ulcer patients, 100 GC patients, and 100 healthy controls. The polymorphisms of the COX-2-765 and -1195 genes were analyzed by polymerase chain reaction and restriction fragment length polymorphisms. Results: The frequencies of the COX-2-1195 GG, GA, and AA genotype were 20%, 60%, and 20% in intestinal-type GC and 8%, 48%, and 44% in diffuse-type GC, respectively (p=0.021). There were no significant differences in the frequency of COX-2-765 genotypes between intestinal-type GC and diffuse-type GC (p=0.603). Age- and sex-adjusted logistic regression analysis showed that the COX-2-1195 AA genotype was the independent risk factor of diffuse-type GC compared with the COX- 2-1195 GG genotype (p=0.041; odds ratio, 6.22; 95% con- fi dence interval, 1.077 to 35.870). Conclusions: The COX-2- 1195 AA genotype may render subjects more susceptible to diffuse-type GC. (Gut Liver 2012;6:321-327)
- Subjects :
- medicine.medical_specialty
Pathology
Stomach neoplasms
Logistic regression
Gastroenterology
law.invention
law
Internal medicine
Genotype
medicine
Diffuse type
Polymorphism
Polymerase chain reaction
Gastrointestinal tract
Hepatology
biology
Alimentary Tract
business.industry
Odds ratio
COX-2
biology.protein
Original Article
Cyclooxygenase
Restriction fragment length polymorphism
business
Subjects
Details
- Language :
- English
- ISSN :
- 20051212 and 19762283
- Volume :
- 6
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Gut and Liver
- Accession number :
- edsair.doi.dedup.....c2c2129323030de364aeb448283c82d5