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Effect of the histamine H3-antagonist clobenpropit on spatial memory deficits induced by MK-801 as evaluated by radial maze in Sprague-Dawley rats
- Source :
- Behavioural Brain Research, 151(1-2), 287-93. Elsevier, Huang, Y W, Hu, W, Chen, Z, Zhang, L L, Shen, H Q, Timmerman, H, Leurs, R & Yanai, K 2004, ' Effect of the histamine H3-antagonist clobenpropit on spatial memory deficits induced by MK-801 as evaluated by radial maze in Sprague-Dawley rats ', Behavioural Brain Research, vol. 151, no. 1-2, pp. 287-93 . https://doi.org/10.1016/j.bbr.2003.09.002
- Publication Year :
- 2004
-
Abstract
- This study was performed to investigate whether or not the histamine H3-antagonist clobenpropit can ameliorate spatial memory deficits induced by MK-801 (0.3 microg per site) as evaluated by an eight-arm radial maze task of rats. A bilateral intrahippocampal (i.h.) injection of clobenpropit (5, 10 microg per site, dose-dependent) markedly improved the working and reference memory deficits induced by MK-801. Its ameliorating effect was potentiated by histidine, but completely antagonized by immepip (2.5 microg per site), a selective H3-agonist. alpha-Fluoromethylhistidine (FMH, 25 microg per site), a selective histidine decarboxylase inhibitor prevented the ameliorating effect of clobenpropit on the working memory deficits induced by MK-801. In addition, the H(1-antagonist pyrilamine, but not the H2-antagonist cimetidine, also inhibited the procognitive effects of clobenpropit. Both FMH and pyrilamine did not significantly modulate the effect of clobenpropit on reference memory. Therefore, the results of this study suggest that the procognitive effects of clobenpropit in MK-801-induced working memory deficits is mediated by increasing endogenous histamine release. In addition, the ameliorating effect of clobenpropit on reference memory might be due to the increased release of neurotransmitters other than histamine.
- Subjects :
- Male
medicine.medical_specialty
Clobenpropit
Histamine Antagonists
Spatial Behavior
Hippocampus
Rats, Sprague-Dawley
Behavioral Neuroscience
chemistry.chemical_compound
Piperidines
Internal medicine
medicine
Animals
Drug Interactions
Maze Learning
Pyrilamine
Analysis of Variance
Memory Disorders
Dose-Response Relationship, Drug
Imidazoles
Thiourea
Antagonist
Immepip
Histidine decarboxylase
Rats
Endocrinology
chemistry
NMDA receptor
Dizocilpine Maleate
Histamine
Subjects
Details
- Language :
- English
- ISSN :
- 01664328
- Volume :
- 151
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Behavioural Brain Research
- Accession number :
- edsair.doi.dedup.....c2bd07a4418999524ea60eb069e6c79a