Inhibitory effect of quinoa and fenugreek extracts on pancreatic lipase and α-amylase under in vitro traditional conditions or intestinal simulated conditions

Ethanol extracts (EE) from fenugreek and quinoa seeds with different total content of inhibitory compounds (TIC, total saponin plus phenolic) were prepared with and without concentration of TIC (CEE –concentrated EE-, and EE, respectively). Their inhibitory activity on pancreatic lipase and α-amylase was assessed by traditional in vitro methods (with or without orbital shaking), and by simulating intestinal digestion. CEE contained higher contents of TIC than EE, being fenugreek superior to quinoa (p
This work was supported by the Ministerio de Economía y Competitividad, Spain (AGL2016-76736-C3-1-R) and the Community of Madrid, Spain (ALIBIRD-CM S2013/ABI-2728). Teresa Herrera thanks the Community of Madrid for her contract (Fondo Social Europeo, Programa Operativo de Empleo Juvenil e Iniciativa de Empleo Juvenil YEI). Joaquín Navarro del Hierro thanks the Ministerio de Educación, Cultura y Deporte, Spain for funding his research with a FPU predoctoral contract (FPU 15/04236).