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The value of microparticles in detecting acute rejection episodes after liver transplantation
- Source :
- Biomarkers. 23:25-32
- Publication Year :
- 2017
- Publisher :
- Informa UK Limited, 2017.
-
Abstract
- Context: Non-invasive markers for diagnosis of acute rejection (AR) following liver transplantation have not been developed, yet.Objective: We analyzed the correlation of plasma microparticle levels (MP) with AR.Materials and Methods: MP (CD4, CD8, CD25, CD31, MHC) of 11 AR patients and 11 controls were analyzed within the first week after transplantation.Results: CD4, CD8 and CD31 positive MP were higher in the AR, whereas overall MP count, CD25 and MHCI positive MP proportions did not differ between both groups.Discussion and Conclusion: MP dynamics within the first period of transplantation could help to clarify on-going mechanisms of immunomodulation.
- Subjects :
- Graft Rejection
Male
0301 basic medicine
CD31
medicine.medical_specialty
Time Factors
CD8 Antigens
Health, Toxicology and Mutagenesis
medicine.medical_treatment
Clinical Biochemistry
Liver transplantation
Biochemistry
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Cell-Derived Microparticles
Internal medicine
medicine
Humans
IL-2 receptor
business.industry
Middle Aged
Liver Transplantation
Platelet Endothelial Cell Adhesion Molecule-1
Transplantation
030104 developmental biology
CD4 Antigens
Immunology
Female
030211 gastroenterology & hepatology
business
CD8
Subjects
Details
- ISSN :
- 13665804 and 1354750X
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Biomarkers
- Accession number :
- edsair.doi.dedup.....c2b54b8d55dc61ed9e1cd339bf013891