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Cytological tumour cell characteristics and reactive small lymphocytes influence patient prognosis in acute and lymphoma type adult T-cell leukaemia/lymphoma
- Source :
- Cytopathology : official journal of the British Society for Clinical Cytology. 30(4)
- Publication Year :
- 2018
-
Abstract
- OBJECTIVE Acute and lymphoma type adult T-cell leukaemia/lymphoma (ATLL) patients show an aggressive clinical course. While some clinical signs indicate good prognosis, definitive cytohistological prognostic factors have yet to be described. METHODS We classified 65 ATLL patients into three groups by tumour cell size and nuclear pleomorphism on fine-needle aspiration and tumour touch smear samples. Semi-quantitative analysis of background small lymphocytes, reactive CD20-positive B cells and CD8-positive T cells was performed. RESULTS Thirty-one patients had pleomorphic lymphoma with predominantly medium-sized cells and coarse granular nuclei. Another 24 patients showed pleomorphic large cell lymphoma with stippled chromatin. The remaining 10 demonstrated monomorphic large lymphoma cells with fine granular chromatin. Patients with pleomorphic lymphoma with medium-sized cells showed significantly higher serum lactate dehydrogenase and lower CD30 and C-MYC expression in lymphoma cells than the other two groups (P = .0216, P < 0.01, respectively). Patients with pleomorphic medium-sized ATLL had few usual small lymphocytes observed on routine morphological examination and showed less concurrent detection of CD20-positive B cells and CD8-positive T cells, both of which were lower than in the other two groups (P = .006, P = .019, respectively). Furthermore, ATLL patients with predominantly medium-sized lymphocytes exhibited a worse prognosis than patients with pleomorphic large cells (P = .0197). Background small lymphocytes and concurrent detection of CD20-positive B cells and CD8-positive T cells may thus be good prognostic factors (P = .011, P = .021, respectively). CONCLUSIONS Morphological features, size of neoplastic cells and background non-neoplastic lymphocyte (B cells and CD8-positive T cells) volume appear to influence the prognosis of patients with aggressive-type ATLL.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Histology
CD30
Lymphocyte
Cell
Adult T-cell leukaemia/lymphoma
030209 endocrinology & metabolism
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
immune system diseases
hemic and lymphatic diseases
Cytology
medicine
Biomarkers, Tumor
Humans
Leukemia-Lymphoma, Adult T-Cell
Lymphocytes
Aged
Aged, 80 and over
B-Lymphocytes
business.industry
Lymphoma, Non-Hodgkin
Large-cell lymphoma
General Medicine
Middle Aged
medicine.disease
Prognosis
Lymphoma
Chromatin
medicine.anatomical_structure
030220 oncology & carcinogenesis
Acute Disease
Female
business
Subjects
Details
- ISSN :
- 13652303
- Volume :
- 30
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Cytopathology : official journal of the British Society for Clinical Cytology
- Accession number :
- edsair.doi.dedup.....c2b3d903bb4fef62a36418d2710e0f65