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Brain imaging reveals covert consciousness during behavioral unresponsiveness induced by propofol
Brain imaging reveals covert consciousness during behavioral unresponsiveness induced by propofol
- Source :
- Scientific Reports, Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Detecting covert consciousness in behaviorally unresponsive patients by brain imaging is of great interest, but a reproducible model and evidence from independent sources is still lacking. Here we demonstrate the possibility of using general anesthetics in a within-subjects study design to test methods or statistical paradigms of assessing covert consciousness. Using noninvasive neuroimaging in healthy volunteers, we identified a healthy study participant who was able to exhibit the specific fMRI signatures of volitional mental imagery while behaviorally unresponsive due to sedation with propofol. Our findings reveal a novel model that may accelerate the development of new approaches to reproducibly detect covert consciousness, which is difficult to achieve in patients with heterogeneous and sometimes clinically unstable neuropathology.
- Subjects :
- Adult
Male
0301 basic medicine
Consciousness
Sedation
media_common.quotation_subject
lcsh:Medicine
Neuroimaging
Neuropathology
Brain mapping
Article
Young Adult
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Hypnotics and Sedatives
lcsh:Science
Propofol
media_common
Brain Mapping
Multidisciplinary
business.industry
lcsh:R
Brain
Magnetic Resonance Imaging
3. Good health
030104 developmental biology
Covert
lcsh:Q
Female
medicine.symptom
business
Neuroscience
Anesthetics, Intravenous
030217 neurology & neurosurgery
Mental image
medicine.drug
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....c2aeb993b3febfac6edd938e4a2a6d2f
- Full Text :
- https://doi.org/10.1038/s41598-018-31436-z