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Leukocyte telomere length and cardiovascular disease in African Americans: The Jackson Heart Study
- Source :
- Atherosclerosis. 266:41-47
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background and aims In European descent populations, shorter leukocyte telomere length (LTL) has been associated with subclinical atherosclerosis, cardiovascular disease (CVD), and mortality, while longer LTL has been associated with greater left ventricular hypertrophy. We evaluated the relationship of LTL with subclinical cardiovascular disease indices and incident clinical events and mortality in African Americans (AAs). Methods Analyses were restricted to 2518 participants of the Jackson Heart Study (JHS) with LTL measured by Southern blot in baseline blood samples. Results Adjusting for established CVD risk factors, longer LTL was significantly associated with lower prevalence of coronary artery calcification (CAC) (odds ratio (OR) = 0.810) per 1 kb increase in LTL; (95% confidence interval [CI] 0.656, 0.9998), p=0.0498). Longer LTL was also associated with higher ankle brachial index (ABI) (β = 0.023; (95% CI 0.004, 0.042), p=0.017) when comparing the highest to the lowest LTL quartile. There were no significant associations between LTL and abdominal aortic calcification, carotid intima-media thickness, or left ventricular mass. After a median follow-up of 9 years, longer LTL was associated with lower risk of incident ischemic stroke (hazard ratio (HR) 0.69 (95% CI 0.48, 0.99), p=0.044) and total mortality (HR 0.81 (95% CI 0.67, 0.97), p=0.026) in age and sex adjusted models, but these associations were no longer significant in fully adjusted models. Conclusions Among a community-based cohort of AAs, longer LTL was nominally associated with lower odds of CAC and increased ABI, indicative of decreased prevalence of subclinical atherosclerosis and peripheral arterial disease. These findings do not offer strong support for LTL as an independent biomarker of CVD risk in AAs.
- Subjects :
- Genetic Markers
Male
0301 basic medicine
medicine.medical_specialty
030204 cardiovascular system & hematology
Left ventricular hypertrophy
Lower risk
Article
03 medical and health sciences
Mississippi
0302 clinical medicine
Risk Factors
Internal medicine
Leukocytes
Odds Ratio
Prevalence
medicine
Humans
Prospective Studies
Prospective cohort study
Aged
Proportional Hazards Models
Subclinical infection
Proportional hazards model
business.industry
Incidence
Hazard ratio
Telomere Homeostasis
Odds ratio
Middle Aged
Telomere
Prognosis
medicine.disease
Black or African American
Logistic Models
030104 developmental biology
Cardiovascular Diseases
Asymptomatic Diseases
Cohort
Linear Models
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 00219150
- Volume :
- 266
- Database :
- OpenAIRE
- Journal :
- Atherosclerosis
- Accession number :
- edsair.doi.dedup.....c2aaaa40b1d9a180a333a1be1795e5fb
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2017.09.016