Corrections to the LDLR Gene Polymorphisms Identified in a Taiwanese Population

193 Sir, As the authors of the article “LDLR and ApoB are Major Genetic Causes of Autosomal Dominant Hypercholesterolemia in a Taiwanese Population” in the October 2007 issue of the Journal of the Formosan Medical Association,1 we found two numbering errors regarding the novel polymorphisms of the LDLR gene we identified in patients with autosomal dominant hypercholesterolemia. In Table 4, the two novel polymorphisms of the LDLR gene were originally numbered as A G1415 in exon 10 and C T2258 in exon 16. However, these numbers are erroneous and they should be relabeled as A G1374 (exon 10, Arg >Arg) and C T2358 (exon 16, Ser>Ser), respectively. The text describing the LDLR gene variants in the results section (page 803, lines 17–18 under the LDLR gene variants subheading) should also be corrected to “A>G at 1374 and C>T at 2358”). Both of the polymorphisms were confirmed by screening 50 control DNA samples (100 alleles) and cross-matching in the LDLR mutation database.2 As the information is important to the understanding of autosomal dominant hypercholesterolemia in Taiwanese people, and as the polymorphisms could also be incorporated into LDLR mutation databases, we hereby write in to formally correct our article. We thank Professor Anne K. Soutar from the Lipoprotein Group of the MRC Clinical Sciences Center in Imperial College London for the discussion of our data.