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Hijacking PrPc-dependent signal transduction: when prions impair Aβ clearance
- Source :
- Frontiers in Aging Neuroscience, Frontiers in Aging Neuroscience, 2014, 6, pp.25. ⟨10.3389/fnagi.2014.00025⟩, Frontiers in Aging Neuroscience, Vol 6 (2014)
- Publication Year :
- 2014
- Publisher :
- HAL CCSD, 2014.
-
Abstract
- International audience; The cellular prion protein PrPc is the normal counterpart of the scrapie prion protein PrPSc, the main component of the infectious agent of transmissible spongiform encephalopathies. The recent discovery that PrPc can serve as a receptor for the amyloid beta (Aβ) peptide and relay its neurotoxicity is sparking renewed interest on this protein and its involvement in signal transduction processes. Disease-associated PrPSc shares with Aβ the ability to hijack PrPc-dependent signaling cascades, and thereby instigate pathogenic events. Among these is an impairment of Aβ clearance, uncovered in prion-infected neuronal cells. These findings add another facet to the intricate interplay between PrPc and Aβ. Here, we summarize the connection between PrP-mediated signaling and Aβ clearance and discuss its pathological implications.
- Subjects :
- Aging
Amyloid
Cognitive Neuroscience
animal diseases
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Scrapie
Biology
lcsh:RC321-571
Mini Review Article
mental disorders
medicine
Prion protein
Receptor
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Neurotoxicity
[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Alzheimer's disease
prion infection
Aβ clearance
medicine.disease
Virology
Cell biology
nervous system diseases
cellular prion protein
Signalling
Αβ clearance
Signal transduction
Alzheimer’s disease
signal transduction
Neuroscience
Infectious agent
Subjects
Details
- Language :
- English
- ISSN :
- 16634365
- Database :
- OpenAIRE
- Journal :
- Frontiers in Aging Neuroscience, Frontiers in Aging Neuroscience, 2014, 6, pp.25. ⟨10.3389/fnagi.2014.00025⟩, Frontiers in Aging Neuroscience, Vol 6 (2014)
- Accession number :
- edsair.doi.dedup.....c285bbf1c8c9ebee47c60a59534ef942