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Juvenile Sjogren's Syndrome
- Source :
- Arthritis Care & Research, Arthritis Care & Research = Arthritis Care and Research, Arthritis Care & Research = Arthritis Care and Research, 2019, 72 (1), pp.78-87. ⟨10.1002/acr.23839⟩, ARTHRITIS CARE & RESEARCH, 72(1), 78-87. Wiley
- Publication Year :
- 2020
-
Abstract
- International audience; Objective. Juvenile Sjögren's syndrome (SS) is a rare, poorly defined, and possibly underdiagnosed condition affecting children and adolescents. The aim of this study was to characterize symptoms and clinical findings of juvenile SS and to explore the clinical application of major salivary gland ultrasonography (SGUS) in patients with juvenile SS. Methods. A cross-sectional multicenter study recruited patients with disease onset until age 18 years (n = 67). Disease characteristics were recorded, and unstimulated whole sialometry and SGUS examination of the parotid and submandibular salivary glands were performed. Results. The female:male ratio was 58:9. The mean age at first symptom was 10.2 years and 12.1 years at diagnosis. Ocular and oral symptoms were noted in 42 of 67 patients (63%) and 53 of 66 patients (80%), respectively. The American-European Consensus Group or American College of Rheumatology/European League Against Rheumatism classification criteria for primary SS were fulfilled by 42 of 67 patients (63%). Pathologic SGUS findings were observed in 41 of 67 patients (61%); 26 of 41 SGUS+ patients (63%) fulfilled primary SS criteria. Salivary gland enlargements/parotitis were noted in 37 of 58 patients and were nonsignificantly associated with SGUS+ status (P = 0.066). The mean levels of saliva were 5.6 ml/15 minutes in SGUS-patients compared to 3.3 ml/15 minutes in the SGUS+ patients (P = 0.049). A total of 36 of 41 SGUS+ patients (88%) were anti-Ro/La+ compared to 14 of 26 SGUS-patients (54%) (P = 0.001). In addition, 24 of 39 SGUS+ patients (62%) were positive for rheumatoid factor (RF), whereas only 5 of 25 SGUS-patients (20%) were RF+ (P = 0.001). Conclusion. Juvenile SS is characterized by a large spectrum of clinical symptoms and findings. Several glandular and extraglandular parameters such as hyposalivation, swollen salivary glands, and autoantibodies are associated with pathologic SGUS findings.
- Subjects :
- Male
medicine.medical_specialty
Saliva
Adolescent
[SDV]Life Sciences [q-bio]
FEATURES
CHILDHOOD
CHILDREN
AMERICAN-COLLEGE
DIAGNOSIS
Gastroenterology
Severity of Illness Index
Pediatrics
Salivary Glands
03 medical and health sciences
0302 clinical medicine
RENAL INVOLVEMENT
AGE
Rheumatology
Major Salivary Gland
Internal medicine
Severity of illness
medicine
Rheumatoid factor
Humans
CLASSIFICATION CRITERIA
Child
Ultrasonography
030203 arthritis & rheumatology
UTILITY
Salivary gland
business.industry
Infant
medicine.disease
3. Good health
medicine.anatomical_structure
Cross-Sectional Studies
Sjogren's Syndrome
Child, Preschool
Female
Original Article
business
CONSENSUS
Rheumatism
Parotitis
Subjects
Details
- Language :
- English
- ISSN :
- 2151464X, 08937524, and 15290123
- Volume :
- 72
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- ARTHRITIS CARE & RESEARCH
- Accession number :
- edsair.doi.dedup.....c284f486c5779eedbc993dc65f7d8aed