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Analysis of the close relationship between human astrocytoma-specific antigens detected by murine monoclonal antibodies and c-kit proto-oncogene product
- Source :
- Biochemical and Biophysical Research Communications. 182:474-480
- Publication Year :
- 1992
- Publisher :
- Elsevier BV, 1992.
-
Abstract
- Tyrosine-specific phosphorylated proteins found exclusively on the cell surface of human astrocytomas were previously identified with murine monoclonal antibodies, designated as GA-17, GB-4 and GC-3. The purpose of this study was to further characterize the antigens and investigate the relationship between them and c-kit protooncogene product. We demonstrated that the antigens had protein kinase activity. Moreover, GA-17 reacted with c-kit protein expressed on the membrane of A172 human glioblastoma cells.
- Subjects :
- Male
medicine.drug_class
Biophysics
Astrocytoma
Biology
Monoclonal antibody
Proto-Oncogene Mas
Biochemistry
Cell Line
Immunoenzyme Techniques
Gene product
Antigen
Antigens, Neoplasm
Proto-Oncogene Proteins
Proto-Oncogenes
medicine
Humans
Phosphotyrosine
Protein kinase A
Molecular Biology
Pan-T antigens
Antibodies, Monoclonal
Glioma
Cell Biology
Middle Aged
Protein-Tyrosine Kinases
Molecular biology
Molecular Weight
Proto-Oncogene Proteins c-kit
Monoclonal
biology.protein
Tyrosine
Antibody
Protein Kinases
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 182
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....c284895a89aac26048138fff40dd28f7