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APPLICATION OF GENETIC SCREENING INFORMATION TO THE MANAGEMENT OF MEDULLARY THYROID CARCINOMA AND MULTIPLE ENDOCRINE NEOPLASIA TYPE 2
- Source :
- Endocrinology and Metabolism Clinics of North America. 25:1-25
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- Application of RET proto-oncogene mutation analysis to the clinical management of MEN 2 and FMTC has simplified and enhanced the power of earlier used screening and treatment efforts for hereditary MTC. The approaches outlined herein are cost-effective, have improved diagnostic accuracy, and hold the promise of improved cure rates for this neoplasm. Further studies to elucidate the mechanism by which these activating mutations cause transformation may lead to other strategies for prevention or treatment of this neoplasm.
- Subjects :
- Oncology
Pathology
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Molecular Sequence Data
Multiple Endocrine Neoplasia Type 2a
Multiple endocrine neoplasia type 2
medicine.disease_cause
Proto-Oncogene Mas
Thyroid carcinoma
Endocrinology
Internal medicine
Proto-Oncogenes
medicine
Carcinoma
Humans
Genetic Testing
Thyroid Neoplasms
Genetic testing
Mutation
Base Sequence
medicine.diagnostic_test
Mechanism (biology)
business.industry
Thyroid
medicine.disease
Pedigree
medicine.anatomical_structure
Medullary carcinoma
Carcinoma, Medullary
business
Subjects
Details
- ISSN :
- 08898529
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Endocrinology and Metabolism Clinics of North America
- Accession number :
- edsair.doi.dedup.....c2702a6b982c529ed37c40ec4c5dada4