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Human Secretory IgM: An Elusive Player in Mucosal Immunity
- Source :
- Trends in immunology. 41(2)
- Publication Year :
- 2019
-
Abstract
- Secretory IgMs (SIgMs) were amongst the first identified immunoglobulins. However, their importance was not fully understood and recent advances have shown they play a key role in establishing and promoting commensal gut tolerance in mice and humans. The true interactions between SIgMs and the microbiota remain controversial and we aim to consolidate current knowledge in this review. Through comprehensive examination of SIgMs and their corresponding B cell secretors in several different pathological immunological contexts, we review the presumed role of these molecules in gut tolerance, inflammatory bowel diseases, and lung immunity. As SIgMs harbor a mostly tolerogenic function, we posit that their inclusion in further immunological research is paramount.
- Subjects :
- biology
Microbiota
Immunology
Inflammatory Bowel Diseases
medicine.disease_cause
Secretory IgM
Autoimmunity
medicine.anatomical_structure
Immunoglobulin M
Immunity
medicine
biology.protein
Immune Tolerance
Immunology and Allergy
Humans
Antibody
Intestinal Mucosa
Mucosal immunity
Immunity, Mucosal
B cell
Subjects
Details
- ISSN :
- 14714981
- Volume :
- 41
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Trends in immunology
- Accession number :
- edsair.doi.dedup.....c26f67c2a96394831721b13106216c9f