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The ?1030/?862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia
- Source :
- Immunogenetics. 55:497-501
- Publication Year :
- 2003
- Publisher :
- Springer Science and Business Media LLC, 2003.
-
Abstract
- Control of HIV-1 viremia and progression to AIDS has been associated with specific HLA genes. The tumor necrosis factor ( TNF) and the non-classical major histocompatibility (MHC) class I chain-related A ( MICA) genes are located in the genomic segment between the HLA class I and II genes and variants of both genes have been identified. We thus analyzed TNF promoter and MICA variants in a well-characterized group of HIV-1 infected individuals with different abilities to control HIV-1 viremia. In our cohort, the -1030/-862-linked TNF promoter single-nucleotide polymorphisms (SNPs), but not MICA variants, are significantly associated with lack of control of HIV-1 viremia ( P=0.03). This association is independent of those HLA-B35 alleles associated with HIV-1 disease progression with which the -862 TNF SNP has previously been independently associated. Thus, non-randomly associated genes near the TNF locus are likely involved in control of HIV-1 viremia.
- Subjects :
- biology
Tumor Necrosis Factor-alpha
Histocompatibility Antigens Class I
Immunology
virus diseases
HIV Infections
Viremia
Single-nucleotide polymorphism
Human leukocyte antigen
medicine.disease
Major histocompatibility complex
Polymorphism, Single Nucleotide
Virology
Host-Parasite Interactions
HIV-1
Genetics
medicine
biology.protein
Humans
SNP
Tumor necrosis factor alpha
Allele
Promoter Regions, Genetic
Gene
Subjects
Details
- ISSN :
- 14321211 and 00937711
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Immunogenetics
- Accession number :
- edsair.doi.dedup.....c25cca0b65fb8500c48f5692c7eab14b