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Plasma monocyte chemotactic protein-1 levels at 24 hours are a biomarker of primary graft dysfunction after lung transplantation
- Source :
- Translational research : the journal of laboratory and clinical medicine, vol 160, iss 6
- Publication Year :
- 2012
- Publisher :
- eScholarship, University of California, 2012.
-
Abstract
- Monocyte chemotactic protein-1 (MCP-1), also known as "chemokine ligand 2" (CCL2), is a monocyte-attracting chemokine produced in lung epithelial cells. We previously reported an association of increased levels of plasma MCP-1 with primary graft dysfunction (PGD) after lung transplantation in a nested case-control study of extreme phenotypes using a multiplex platform. In this study, we sought to evaluate the role of plasma MCP-1 level as a biomarker across the full spectrum of PGD. We performed a prospective cohort study of 108 lung transplant recipients within the Lung Transplant Outcomes Group cohort. Plasma MCP-1 levels were measured pretransplantation and 6 and 24 hours after transplantation. The primary outcome was development of grade 3 PGD within 72 hours of transplant, with secondary analyses at the 72-hour time point. Multivariable logistic regression was used to evaluate confounding. Thirty subjects (28%) developed PGD. Median MCP-1 measured at 24 hours post-transplant was elevated in subjects with PGD (167.95 vs 103.5 pg/mL, P = .04). MCP-1 levels at 24 hours were associated with increased odds of grade 3 PGD after lung transplantation (odds ratio for each 100 pg/mL, 1.24; 95% confidence interval, 1.00-1.53) and with grade 3 PGD present at the 72-hour time point (odds ratio for each 100 pg/mL, 1.57; 95% confidence interval, 1.18-2.08), independent of confounding variables in multivariable analyses. MCP-1 levels measured preoperatively and 6 hours after transplant were not significantly associated with PGD. Persistent elevations in MCP-1 levels at 24 hours are a biomarker of grade 3 PGD post-transplantation. Monocyte chemotaxis may play a role in the pathogenesis of PGD.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Monocyte chemotaxis
medicine.medical_treatment
Clinical Sciences
Primary Graft Dysfunction
Gastroenterology
Cohort Studies
Idiopathic pulmonary fibrosis
Clinical Research
Physiology (medical)
Internal medicine
medicine
Odds Ratio
Lung transplantation
Humans
Prospective Studies
Prospective cohort study
General Clinical Medicine
Chemokine CCL2
Transplantation
business.industry
Respiration
Biochemistry (medical)
Public Health, Environmental and Occupational Health
General Medicine
Organ Transplantation
respiratory system
Middle Aged
medicine.disease
Nested case-control study
Immunology
Artificial
Biomarker (medicine)
lipids (amino acids, peptides, and proteins)
Female
business
Biomarkers
Lung Transplantation
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Translational research : the journal of laboratory and clinical medicine, vol 160, iss 6
- Accession number :
- edsair.doi.dedup.....c2457d67b1cd4e9730573b15268d3500