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Protein kinase C subspecies in hippocampus and striatum of reserpinized rat brain
- Source :
- Brain Research. 634:127-130
- Publication Year :
- 1994
- Publisher :
- Elsevier BV, 1994.
-
Abstract
- Protein kinase C (PKC) (alpha) and (beta) immunoreactivities were determined in the cytosolic and particulate fractions of the hippocampus and striatum after single and repetitive, intraperitoneal administration of reserpine. Significant decrease of PKC(alpha) immunoreactivities was observed in the particulate fractions of both striatum and hippocampus. Compared with the alteration of PKC(alpha), the decreased immunoreactivity of PKC(beta) was only observed in the particulate fraction of the hippocampus, associated with the increase in the cytosolic fraction. These findings suggest a novel mechanism regulating the distribution of PKC. The topographical selectivity in the present study may indicate the importance of the alteration of PKC(beta) in the pathophysiological mechanism in Alzheimer's disease.
- Subjects :
- Male
medicine.medical_specialty
Reserpine
Central nervous system
Hippocampus
Striatum
Biology
Western blot
Biogenic amine
Internal medicine
medicine
Animals
Biogenic Monoamines
Rats, Wistar
Molecular Biology
Protein Kinase C
Protein kinase C
chemistry.chemical_classification
medicine.diagnostic_test
General Neuroscience
Corpus Striatum
Rats
Cytosol
Endocrinology
medicine.anatomical_structure
nervous system
chemistry
Neurology (clinical)
Developmental Biology
medicine.drug
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 634
- Database :
- OpenAIRE
- Journal :
- Brain Research
- Accession number :
- edsair.doi.dedup.....c23653cdb6d0e732dc263c333939c5f8