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Curcumin improves alcoholic fatty liver by inhibiting fatty acid biosynthesis
- Source :
- Toxicology and Applied Pharmacology. 328:1-9
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Alcoholic fatty liver is a threat to human health. It has been long known that abstinence from alcohol is the most effective therapy, other effective therapies are not available for the treatment in humans. Curcumin has a great potential for anti-oxidation and anti-inflammation, but the effect on metabolic reconstruction remains little known. Here we performed metabolomic analysis by gas chromatography/mass spectrometry and explored ethanol pathogenic insight as well as curcumin action pattern. We identified seventy-one metabolites in mouse liver. Carbohydrates and lipids were characteristic categories. Pathway analysis results revealed that ethanol-induced pathways including biosynthesis of unsaturated fatty acids, fatty acid biosynthesis and pentose and glucuronate interconversions were suppressed by curcumin. Additionally, ethanol enhanced galactose metabolism and pentose phosphate pathway. Glyoxylate and dicarboxylate metabolism and pyruvate metabolism were inhibited in mice fed ethanol diet plus curcumin. Stearic acid, oleic acid and linoleic acid were disease biomarkers and therapical biomarkers. These results reflect the landscape of hepatic metabolism regulation. Our findings illustrate ethanol pathological pathway and metabolic mechanism of curcumin therapy.
- Subjects :
- Male
0301 basic medicine
Curcumin
Glucuronate
Linoleic acid
Glyoxylate and dicarboxylate metabolism
Pentose phosphate pathway
Biology
Toxicology
Pentose Phosphate Pathway
Mice
03 medical and health sciences
chemistry.chemical_compound
Glucuronic Acid
Animals
Metabolomics
Pharmacology
Ethanol
Anti-Inflammatory Agents, Non-Steroidal
Fatty Acids
Central Nervous System Depressants
Galactose
Oleic acid
030104 developmental biology
Liver
chemistry
Biochemistry
Alcoholic fatty liver
Drug metabolism
Fatty Liver, Alcoholic
Subjects
Details
- ISSN :
- 0041008X
- Volume :
- 328
- Database :
- OpenAIRE
- Journal :
- Toxicology and Applied Pharmacology
- Accession number :
- edsair.doi.dedup.....c225e02d1192c3e3a99bdd7bdd0519c4