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Disulfiram neuropathy: two case reports
- Source :
- Journal of Medical Case Reports
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Background Neuropathy is a rare adverse side effect of disulfiram therapy and is under-recognized. There have been few case reports documenting this side effect. Case presentation Two cases of disulfiram peripheral neuropathy are discussed. The first case is that of a 25-year-old Caucasian woman who was exposed to disulfiram therapy for a total of 8 months and developed pain and stiffness that prevented her from walking. The second case is that of a 46-year-old Caucasian woman who developed sudden-onset numbness in her lower extremities with progression to pain. Her symptoms improved over the course of 2 months after cessation of disulfiram therapy. In both cases, symptoms improved after cessation of disulfiram therapy. Conclusions Disulfiram neuropathy occurs in persons with a history of chronic alcohol use. It is under-recognized and often attributed to alcoholic neuropathy given its comorbidity with alcoholic neuropathy. A greater understanding of this side effect may reduce neurologic complications related to disulfiram neuropathy and aid in early withdrawal of this offending agent.
- Subjects :
- Adult
medicine.medical_specialty
Side effect
MEDLINE
Alternative medicine
Case Report
Hypesthesia
03 medical and health sciences
0302 clinical medicine
Surgical oncology
Disulfiram
Humans
Medicine
Intensive care medicine
Medicine(all)
business.industry
Peripheral Nervous System Diseases
General Medicine
Middle Aged
medicine.disease
Alcoholism
Alcohol Deterrents
Neuralgia
Female
030211 gastroenterology & hepatology
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 17521947
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Medical Case Reports
- Accession number :
- edsair.doi.dedup.....c223227c47afdfe83fa3dac760f305c6