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Breast Cancer Brain Metastasis Response to Radiation After Microbubble Oxygen Delivery in a Murine Model
- Publication Year :
- 2019
-
Abstract
- OBJECTIVES—: Hypoxic cancer cells have been shown to be more resistant to radiation therapy than normoxic cells. Hence, this study investigated whether ultrasound (US)-induced rupture of oxygen-carrying microbubbles (MBs) would enhance the response of breast cancer metastases to radiation. METHODS—: Nude mice (n = 15) received stereotactic injections of brain-seeking MDA-MB-231 breast cancer cells into the right hemisphere. Animals were randomly assigned into 1 of 5 treatment groups: no intervention, 10 Gy radiation using a small-animal radiation research platform, nitrogen-carrying MBs combined with US-mediated MB rupture immediately before 10 Gy radiation, oxygen-carrying MBs immediately before 10 Gy radiation, and oxygen-carrying MBs with US-mediated MB rupture immediately before 10 Gy radiation. Tumor progression was monitored with 3-dimensional US, and overall survival was noted. RESULTS—: All groups except those treated with oxygen-carrying MB rupture and radiation had continued rapid tumor growth after treatment. Tumors treated with radiation alone showed a mean increase in volume ± SD of 337% ± 214% during the week after treatment. Tumors treated with oxygen-carrying MBs and radiation without MB rupture showed an increase in volume of 383% ± 226%. Tumors treated with radiation immediately after rupture of oxygen-carrying MBs showed an increase in volume of only 41% ± 1% (P = 0.045), and this group also showed a 1 week increase in survival time. CONCLUSIONS—: Adding US-ruptured oxygen-carrying MBs to radiation therapy appears to delay tumor progression and improve survival in a murine model of metastatic breast cancer.
- Subjects :
- medicine.medical_treatment
Mice, Nude
Breast Neoplasms
Article
030218 nuclear medicine & medical imaging
03 medical and health sciences
Mice
Random Allocation
0302 clinical medicine
Breast cancer
Medicine
Animals
Radiology, Nuclear Medicine and imaging
Radiosensitivity
Ultrasonography
Drug Carriers
030219 obstetrics & reproductive medicine
Microbubbles
Radiological and Ultrasound Technology
business.industry
Brain Neoplasms
medicine.disease
Metastatic breast cancer
Radiation therapy
Oxygen
Disease Models, Animal
Tumor progression
Cancer cell
Female
business
Nuclear medicine
Brain metastasis
Contrast-enhanced ultrasound
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....c21a25200a0943e746d4e8aad0196967