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Body Weight Variability and the Risk of Cardiovascular Outcomes and Mortality in Patients With Type 2 Diabetes: A Nationwide Cohort Study
- Source :
- Diabetes Care. 43:2234-2241
- Publication Year :
- 2020
- Publisher :
- American Diabetes Association, 2020.
-
Abstract
- OBJECTIVE Obesity and type 2 diabetes are risk factors for cardiovascular diseases and mortality, and they commonly result in weight variabilities. We aimed to investigate the association between body weight variability and risk of major cardiovascular outcomes and mortality in individuals with type 2 diabetes using large-scale, nationwide cohort data on the Korean population. RESEARCH DESIGN AND METHODS We enrolled 624,237 individuals with type 2 diabetes who underwent health examinations provided by the Korean National Health Insurance System between 2009 and 2010, with three or more body weight measurements within 5 years since enrollment and followed up until the end of 2017. We assessed body weight variability using four indices, including variability independent of the mean (VIM). A multivariate-adjusted Cox proportional hazards regression analysis was performed. RESULTS During the follow-up, 15,832, 25,038, and 44,716 cases of myocardial infarction (MI), stroke, and all-cause mortality, respectively, were recorded. Body weight variability was associated with increased risks of major cardiovascular outcomes after adjusting for confounding variables. Compared with the hazard ratios (HRs) of the lowest quartile group, the HRs (95% CIs) of the highest quartile group of VIM for body weight were 1.15 (1.10–1.20), 1.22 (1.18–1.26), and 1.58 (1.53–1.62) for MI, stroke, and all-cause mortality, respectively. CONCLUSIONS Body weight variability was associated with increased risks of MI, stroke, and all-cause mortality in patients with type 2 diabetes and may be a predictor of cardiovascular outcomes in such patients. Appropriate interventions to maintain stable weight could positively influence health outcomes in patients with type 2 diabetes.
- Subjects :
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Myocardial Infarction
030209 endocrinology & metabolism
Type 2 diabetes
Body Weight Maintenance
Cohort Studies
Young Adult
03 medical and health sciences
0302 clinical medicine
Risk Factors
Cause of Death
Internal medicine
Diabetes mellitus
Republic of Korea
Internal Medicine
medicine
Humans
Obesity
030212 general & internal medicine
Stroke
Aged
Aged, 80 and over
Advanced and Specialized Nursing
business.industry
Body Weight
Hazard ratio
Middle Aged
Prognosis
medicine.disease
Diabetes Mellitus, Type 2
Quartile
Cohort
Female
business
Diabetic Angiopathies
Cohort study
Subjects
Details
- ISSN :
- 19355548 and 01495992
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Diabetes Care
- Accession number :
- edsair.doi.dedup.....c2087bad8f245f18de932d1e8a1993f8
- Full Text :
- https://doi.org/10.2337/dc19-2552